ADENOCARCINOMA NOT OTHERWISE SPECIFIED OF SALIVARY GLANDS: HISTOPATHOLOGICAL, PROTEIC AND GENETIC STUDY

• Grant number: 15/16056-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2016
• End date: October 13, 2016
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Pablo Agustin Vargas
• Grantee: Felipe Paiva Fonseca
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Salivary gland tumors account for approximately 5% of all head and neck tumors, with a global annual incidence of 0.4 to 13.5 cases/100.000 persons. Because of its wide microscopic diversity the diagnosis of these neoplasms becomes a frequent pitfall in the histopathology routine and the classification of this group of lesions is frequently being updated. In the last years new entities have been recognized, exhibiting reproducible clinical and microscopic features, possibly being included in the next classification of salivary gland tumors of the World Health Organization. However, approximately 20% of the salivary gland malignancies are still diagnosed as adenocarcinomas not otherwise specified (NOS), representing a highly heterogeneous group whose diagnosis represents the impossibility of recognizing any other entity. Hence, the objective of this study is to clinicopathologicaly and molecularly characterize cases diagnosed as adenocarcinomas NOS of salivary glands by retrospectively retrieving approximately 100 cases from the files of the State University of Campinas and the University of Pretoria (South Africa) and submitting them to histopathological analysis, immunohistochemical reactions against AE1/AE3, CK7, p63, smooth muscle actin, calponin, CD56, S100 and Ki67 antigens, mass spectrometry and fluorescence in situ hybridization (FISH). Clinical and follow-up data will be retrieved from patients' medical charts. By the end of this project we look forward to better characterizing this group of malignant tumors, possibly identifying new entities that may exhibit similar clinical behavior and reproducible microscopic and molecular profiles, allowing an improvement of the classification of these neoplasms.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FONSECA, FELIPE PAIVA; SOARES MACEDO, CAROLINA CARNEIRO; DOS SANTOS COSTA, SARA FERREIRA; PAES LEME, ADRIANA FRANCO; RODRIGUES, ROMENIA RAMOS; REBELO PONTES, HELDER ANTONIO; ALTEMANI, ALBINA; VAN HEERDEN, WILLIE F. P.; MARTINS, MANOELA DOMINGUES; DE ALMEIDA, OSLEI PAES; et al. Mass spectrometry-based proteome profile may be useful to differentiate adenoid cystic carcinoma from polymorphous adenocarcinoma of salivary glands. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 128, n. 6, p. 639-650, DEC 2019. (09/54067-3, 15/16056-0)

DO AMARAL-SILVA, GLEYSON KLEBER; MARTINS, MANOELA DOMINGUES; REBELO PONTES, HELDER ANTONIO; FREGNANI, EDUARDO RODRIGUES; LOPES, MARCIO AJUDARTE; FONSECA, FELIPE PAIVA; VARGAS, PABLO AGUSTIN. Mismatch repair system proteins in oral benign and malignant lesions. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 46, n. 4, p. 241-245, APR 2017. (15/16056-0, 15/21520-8)