Comparison between the effects of sevoflurane and isoflurane on hemostasis in bitches under ovarian salpingohysterectomy

• Grant number: 15/19638-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Francisco José Teixeira Neto
• Grantee: André Augusto Justo
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Sevoflurane and isoflurane are commomly used in veterinary medicine for inhalatory anesthesia. Even though both of them induce cardiorespiratory depression in similar magnitude (cardiovascular and respiratory dose-dependent depression), sevoflurane holds some features that make its use more suitable in certain situations. In prolonged surgeries, for example, it is advised to proceed with the surgery under the use of sevoflurane, once it is more briefly removed from the organism, considering its blood/gas solubility coeficient is higher when compared to isoflurane's. The use of sevoflurane ought to be considered during mask induction of anesthesia as well, given it does not have a pungent smell. However, despite sevoflurane is a safe drug in terms of enabling quick control in the deepness of the anesthesia and rapid induction/recovery from anesthesia, studies in human patients proves such anesthetic may inhibit platelet function and increase intraoperative bleeding in comparison to isoflurane. Although, it is not known whether these results can be interpreted as the same for animal species, in a way the aim of this study is to assess if sevoflurane keeps its anti-platelet property in dogs.