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Quality evaluation and pharmaceutical equivalence of doxycycline in tablets

Grant number: 15/21957-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date: March 01, 2016
End date: February 28, 2018
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Hérida Regina Nunes Salgado
Grantee:Loren Fernanda Ghidini
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Doxycycline is a broad spectrum antimicrobial agent, synthetic derivative of the oxytetracycline, used in several countries for the treatment of infectious diseases as well as additives in animal feed to facilitate their growth. This medicine is part of the list of the Brazilian Unified Health System (SUS) and its distribution is free under medical prescription. The Brazilian Unified Health System is one of the largest public systems of health in the world that ensures full access, universal and free to the entire population of the country. On this system there is a program called "Farmácia popular do Brasil", which aims to provide medicines, such as doxycycline, for free or at a low cost to the population. Therefore, is notable the easy access that population has about this antimicrobial agent, so is necessary a research to evaluate the quality and the equivalence of the tablets which are being distributed. This study aims to evaluate the quality and the equivalence of doxycycline tablets currently sold, by determining of (I) the average weight, (II) hardness, (III), friability, (IV) disintegration, (V) the active principle content, (VI) content uniformity and (VII) in vitro dissolution of the reference medicine of doxycycline, two generics and two similar products. The results of this study will be published in an international journal and will be presented in scientific events. This search comprises a current and an innovative theme, and it is extremely important for quality control area of drugs and medicines.

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