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Short term stability study of doxicicline hyclate ín tablets

Grant number: 13/25174-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2014
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Hérida Regina Nunes Salgado
Grantee:Janaína Oliveira de Barros
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Doxycycline hyclate is a semisythetic broad spectrum antibiotic derivated from oxytetracycline used in human medicine as an anti infectious for general illnesses and specific diseases such as plague and trachoma and also as an anti-paristic in cases of malaria. In veterinary medicine it is used as a food supplement. The pharmaceutical is shown in the National List of Essential Pharmaceuticals thus it is available in the Unified Health System (hereby SUS) and it is free delivered at Basic Health Unities. It is also available in The Popular Pharmacy Program at a lower cost. In Brazil doxycycline hyclate is marketd by pharmaceutical companies Apotex, EMS, Germerd, Hexal, Legrand, Neo Química, Neovita, Pfizer, Ranbaxy, Sanval, Teuto and União Química and it is offered as pharmaceutical preparations: pellets, capsules, tablets and syrup. The present study aims to develop a short term stability study of doxycycline hyclate in tablets and in raw material using turbidimetric method, ultraviolet spectrophotometry and high performance liquid chromatography.Key words: high performance liquid chromatography, ultraviolet spectrophotometry, short term stability study, doxycycline hyclate, turbidity, tablets.