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Synthesis of fluorescent nanoparticles using betalains

Grant number: 15/25629-4
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2016
Effective date (End): November 03, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Erick Leite Bastos
Grantee:Arthur Bonfá Fernandes
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/25187-2 - Betalains as mediators in photoinduced electron transfer processes, BE.EP.DD

Abstract

The use of fluorescence in Cell Biology has contributed to expand the general understanding of the molecular basis of biological processes. Single molecule fluorescence, laser-induced fluorescence of biomolecules, tags and probes with non-linear optical properties, and fluorescent nanoparticles are state of the art in this field. In this PhD project, we propose to manufacture highly monodisperse fluorescent nanoparticles using betalains, a class of plant pigments, as reducing and stabilizing agents. The interaction of the nanoparticles obtained with animal cell lines will be studied by confocal microscopy experiments and the results will be analyzed considering structure-property relationships. Five groups of model-betalains will be semisynthesized and characterized (structure and photophysical and redox properties) for this study. Nanoparticles will be characterized by different techniques, including: electron microscopy, atomic force microscopy, X-ray scattering and X-rays photoelectron spectroscopy. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREITAS-DORR, B. C.; MACHADO, C. O.; PINHEIRO, A. C.; FERNANDES, A. B.; DORR, F. A.; PINTO, E.; LOPES-FERREIRA, M.; ABDELLAH, M.; SA, J.; RUSSO, L. C.; FORTI, F. L.; GONCALVES, L. C. P.; BASTOS, L. L. A metal-free blue chromophore derived from plant pigments. SCIENCE ADVANCES, v. 6, n. 14 APR 2020. Web of Science Citations: 0.
FERNANDES, ARTHUR B.; PAVLIUK, V, MARIIA; PAUN, CRISTINA; CARVALHO, ALEXANDRINA C.; NOMURA, CASSIANA S.; LEWIN, ERIK; LINDBLAD, REBECKA; CAMARGO, PEDRO H. C.; SA, JACINTO; BASTOS, ERICK L. Recoverable and Reusable Polymer Microbead-Supported Metal Nanocatalysts for Redox Chemical Transformations. ACS APPLIED NANO MATERIALS, v. 3, n. 2, p. 1722-1730, FEB 2020. Web of Science Citations: 0.
REIS, JOEL S.; FERNANDES, ARTHUR B.; FREITAS-DORR, BARBARA C.; BASTOS, ERICK L.; STEFANI, HELIO A. Oxazoline as acceptor moiety for excited-state intramolecular proton transfer. Tetrahedron, v. 74, n. 48, p. 6866-6872, NOV 29 2018. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.