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Direct estimates of evolutionary parameters via QTL analysis

Grant number: 15/21811-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): April 11, 2016
Effective date (End): September 10, 2016
Field of knowledge:Biological Sciences - Genetics - Quantitative Genetics
Principal Investigator:Gabriel Henrique Marroig Zambonato
Grantee:Diogo Amaral Reboucas Melo
Supervisor abroad: Jason B. Wolf
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : University of Bath, England  
Associated to the scholarship:14/26262-4 - Direct estimates of evolutionary parameters via quantitative trait loci analysis, BP.DR


Since morphological evolution and response to selection depend on the standing genetic variation available in a given population, how this covariation evolves is a central question in biology. The genetic covariation structure is determined by the sum of genetic effects, including mainly pleiotropic effects and linkage disequilibrium. In this internship we intend to use data from a cross between inbredstrains of mice with different sizes to study the relation between pleiotropic geneticeffects and the morphological divergence between there strains. Using quantitativetrait loci mapping techniques, quantitative genetics and morphological measurements, we intend to use this powerful experimental system to further our understanding on the evolution of genetic covariation and its genetic basis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MELO, DIOGO; MARROIG, GABRIEL; WOLF, JASON B. Genomic Perspective on Multivariate Variation, Pleiotropy, and Evolution. JOURNAL OF HEREDITY, v. 110, n. 4, SI, p. 479-493, JUN 2019. Web of Science Citations: 0.

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