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Direct estimates of evolutionary parameters via QTL analysis

Grant number: 15/21811-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): April 11, 2016
Effective date (End): September 10, 2016
Field of knowledge:Biological Sciences - Genetics - Quantitative Genetics
Principal Investigator:Gabriel Henrique Marroig Zambonato
Grantee:Diogo Amaral Reboucas Melo
Supervisor: Jason B. Wolf
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Bath, England  
Associated to the scholarship:14/26262-4 - Direct estimates of evolutionary parameters via quantitative trait loci analysis, BP.DR

Abstract

Since morphological evolution and response to selection depend on the standing genetic variation available in a given population, how this covariation evolves is a central question in biology. The genetic covariation structure is determined by the sum of genetic effects, including mainly pleiotropic effects and linkage disequilibrium. In this internship, we intend to use data from a cross between inbred strains of mice with different sizes to study the relation between pleiotropic genetic effects and the morphological divergence between their strains. Using quantitative trait loci mapping techniques, quantitative genetics and morphological measurements, we intend to use this powerful experimental system to further our understanding of the evolution of genetic covariation and its genetic basis. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MELO, DIOGO; MARROIG, GABRIEL; WOLF, JASON B.. Genomic Perspective on Multivariate Variation, Pleiotropy, and Evolution. JOURNAL OF HEREDITY, v. 110, n. 4, SI, p. 479-493, . (15/21811-2, 11/14295-7, 14/26262-4, 13/50402-8)
MELO, DIOGO; MARROIG, GABRIEL; WOLF, JASON B.. Genomic Perspective on Multivariate Variation, Pleiotropy, and Evolution. JOURNAL OF HEREDITY, v. 110, n. 4, p. 15-pg., . (11/14295-7, 15/21811-2, 13/50402-8, 14/26262-4)

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