Reproductive outcomes of antioxidant therapy with chrysin in experimental varicocele in rats

• Grant number: 15/26309-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2016
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Wilma de Grava Kempinas
• Grantee: Gabriela Missassi
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Varicocele, also known as testicular varicose veins, is considered a major cause of male infertility. This condition is the result of a malfunction or absence of the valves in the spermatic veins that have a retrograde blood flow, resulting in venous dilation of pampiniform plexus. Its effects involve hormonal dysfunction, sperm DNA damage, hypoxia and testicular hyperthermia, reflux of adrenal/renal toxic metabolites and increased reactive oxygen species in seminal plasma. Considering its impacts and high incidence, several treatments have been proposed to minimize and/or reverse the damage caused by varicocele, among them there are surgical interventions and antioxidant therapy, which aims to improve sperm parameters before and/or after surgery. In this context, the purpose of this study is to evaluate aspects of reproductive histophysiology, with emphasis on sperm quality of rats with surgically induced varicocele and the potential effects of treatment with chrysin. This flavonoid is found in high concentrations in honey, propolis and plant extracts, and besides having anticancer activity, anti-inflammatory, anti-hypertensive and anti-aging, is known as a powerful antioxidant. Several studies report that this compound, besides having a great protective activity against the damage caused by oxidative stress, it has a positive impact on sperm parameters. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MISSASSI, GABRIELA; BORGES, CIBELE DOS SANTOS; ROSA, JOSIANE DE LIMA; VILLELA E SILVA, PATRICIA; MARTINS, JR., AIRTON DA CUNHA; BARBOSA, JR., FERNANDO; KEMPINAS, WILMA DE GRAVA. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. (15/26309-3)

MISSASSI, GABRIELA; BORGES, CIBELE DOS SANTOS; ROSA, JOSIANE DE LIMA; VILLELA E SILVA, PATRICIA; MARTINS, AIRTON DA CUNHA, JR.; BARBOSA, FERNANDO, JR.; KEMPINAS, WILMA DE GRAVA. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2017, p. 12-pg., 2017-01-01. (15/26309-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MISSASSI, Gabriela. Reproductive outcomes of antioxidant therapy with chrysin in experimental varicocele in rats. 2017. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.