Objective sleep evaluation and mean telomere length in a sample of São Paulo city

• Grant number: 15/17549-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2016
• End date: June 30, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Sergio Tufik
• Grantee: Priscila Farias Tempaku
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Sleep is one of the most important physiological processes for the healthy maintenance of many organisms. Significant alterations in sleep patterns and the quantity and quality of sleep are found as people get older. Besides, the elderly population has been found to have a higher prevalence of sleep disturbances. Concurrently with increasing age, there is also the shortening of telomeres, structures located in the terminal region of chromosomes, as a result of cellular senescence mechanisms. Telomere shortening has been investigated as a marker of biological aging and age-related conditions. Taking into consideration the simultaneous occurrence of telomere shortening and changes in sleep structure with aging, the present proposal aims to measure the mean telomere length of leukocytes in a sample from EPISONO project, a single-center study that described the prevalence of the main sleep disorders in a representative adult population (20 to 80 years) sample of São Paulo city. For the present project, DNA collected and extracted from peripheral blood of 1042 individuals from EPISONO will be used. Mean telomere length of leukocytes will be measured by quantitative real-time polymerase chain reaction method, using only one fluorophore (MMqPCR). It will be verified the association between relative telomere length and socio-demographic variables, objective and subjective sleep parameters e the presence of sleep disorders. Thus, the project aims to contribute to the identification of potential markers that may assist in the diagnosis or help identify therapeutic targets of sleep disorders or related phenotypes in this representative sample of the population of São Paulo. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEMPAKU, PRISCILA F.; HIROTSU, CAMILA; SILVA, VINICIUS D.; TUFIK, SERGIO. Letter to the editor: Sleep as a contributing factor in the relationship between depression and cell aging. JOURNAL OF PSYCHIATRIC RESEARCH, v. 82, p. 48-49, NOV 2016. (15/17549-0, 14/15259-2)

TEMPAKU, PRISCILA FARIAS; MAZZOTTI, DIEGO ROBLES; HIROTSU, CAMILA; ANDERSEN, MONICA LEVY; XAVIER, GABRIELA; MAURYA, PAWAN KUMAR; RIZZO, LUCAS BORTOLOTTO; BRIETZKE, ELISA; BELANGERO, SINTIA IOLE; BITTENCOURT, LIA; et al. The effect of the severity of obstructive sleep apnea syndrome on telomere length. ONCOTARGET, v. 7, n. 43, p. 69216-69224, OCT 25 2016. (15/17549-0, 14/15259-2)

TEMPAKU, PRISCILA; HIROTSU, CAMILA; MAZZOTTI, DIEGO; XAVIER, GABRIELA; MAURYA, PAWAN; BRIELZKE, ELISA; BELANGERO, SINTIA; POYARES, DALVA; BITTENCOURT, LIA; TUFIK, SERGIO. Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 14, n. 12, p. 2037-2045, 2018. (15/17549-0, 14/15259-2)

AMARAL JUNIOR, ROSALVO; FRANGE, CRISTINA; TEMPAKU, PRISCILA FARIAS; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Dopaminergic pathways for bruxism: a way forward?. CLINICAL ORAL INVESTIGATIONS, v. 21, n. 9, p. 2875-2876, DEC 2017. (15/17549-0, 14/18722-5)

TEMPAKU, PRISCILA F.; TUFIK, SERGIO; HIROTSU, CAMILA. Commentary: Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease. FRONTIERS IN PHYSIOLOGY, v. 8, p. 3-pg., 2017-04-25. (14/15259-2, 15/17549-0)

GIMENES ALBUQUERQUE, R.; HIROTSU, C.; FARIAS TEMPAKU, P.; TOMIMORI, J.; TUFIK, S.; LEVY ANDERSEN, M.. SLEEP RESTRICTION INCREASES TELOMERE LENGTH IN SKIN OF RATS. Sleep Medicine, v. 40, p. 2-pg., 2017-12-01. (14/15259-2, 15/17549-0, 14/00923-4)

TEMPAKU, PRISCILA F.; TUFIK, SERGIO. The paradigm of obstructive sleep apnea in aging: interactions with telomere length. Sleep Medicine, v. 48, p. 2-pg., 2018-08-01. (15/17549-0)

TEMPAKU, PRISCILA FARIAS; RAMIREZ ARRUDA, JULIANA; MAZZOTTI, DIEGO ROBLES; GONCALVES, BRUNO S. B.; PEDRAZZOLI, MARIO; BITTENCOURT, LIA; TUFIK, SERGIO. Characterization of bimodal chronotype and its association with sleep: A population-based study. CHRONOBIOLOGY INTERNATIONAL, v. 34, n. 4, p. 504-510, MAY 2017. (15/17549-0)

TEMPAKU, P.; RAMIREZ, J.; MAZZOTTI, D.; GONCALVES, B.; PEDRAZZOLI, M.; BITTENCOURT, L.; TUFIK, S.. CHARACTERIZATION OF BIMODAL CHRONOTYPE AND ITS ASSOCIATION WITH SLEEP: A POPULATION-BASED STUDY. Sleep Medicine, v. 40, p. 1-pg., 2017-12-01. (15/17549-0)