Studies of the efficiency of encapsulation and the profile of insulin releases in acrylic acid, N-isopropylacrylamide and chitosan polymeric nanoparticles

• Grant number: 16/06167-2
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): June 01, 2016
• Effective date (End): May 31, 2017
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal researcher: Reinaldo Giudici
• Grantee: Marcela Ferreira de Carvalho
• Home Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The Diabetes Mellitus is a chronic disease that represents a big challenge for the health system worldwide. In 2007, Brazil ranked 7 among countries with the highest number of diabetics, with 6,9 million of registered cases, based on datas from World Health Organization (WHO). According to some predictions, it is estimated that until 2025 this number will raise to 17,6 millions of diabetic people. Currently, the treatment of diabetes has been made through the administration of insulin by parenteral route, which is unpleasant to the patient. With the porpoise of minimizing the frequency of administration and searching for a less painful route for the patients treatment, studies have been made on the attempt of getting a great excipient by oral route for the insulin, which cannot be degraded and still have a great bioavailability on the liberation local. Considering the challenges, the polymeric nanoparticles have been promising candidates as a vehicle to a controlled drug delivery by oral route due to colloidal stability, chemical resistance, physical-chemical characteristics and easy production. In this way, this project has the objective of studying the interaction between insulin and microgels sensible to Ph with different compositions of acrylic acid, N-isopropylacrylamide and chitosan, through the efficiency of drug encapsulment in particles and the profile of the liberation in a long term. This study is a kick start for the development of a polymeric carrier for a controlled liberation of insulin by oral route. (AU)