Genetic inheritance modulation by physical training induced by interleukin-6

• Grant number: 15/24399-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2016
• End date: December 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Ronaldo de Carvalho Araújo
• Grantee: Thaís Alves da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

It is currently established that genetic profile transmitted to the offspring by DNA sequence involves the passage of important epigenetic information which include: DNA's methylation by DNA methyltransferases (Dnmt); histones acetylation by histone acetyltransferases (HAT) or histone deacetylases (HDAC); and inhibition of protein production by microRNAs. Nutritional experiences of both parents during or before conception, as paternal obesity, have epigenetic effects in embryonic life which can result in adulthood implications, as a greater obesity tendency. Physical exercise promotes adiposity reduction and sexual function improvement of obese males, in addition, to reduce the adult life obese propensity of offspring, however, the mechanism responsible for the action of exercise as a transgenerational genetic factor has not been established yet. Interleukin-6 (IL-6) is the main myokine delivered by contracting muscle, it mainly acts by activation of JAK/ STAT, JAK/ERK, JAK/PI3K, and JAK/MAPK which develop important anti-inflammatory and metabolic effects. Furthermore, the role of IL-6 on testis when it is delivered by the muscle is not present in the literature, only its inflammatory effect, which acts negatively on spermatogenesis by blood-testis barrier's and Sertoli cells' regulation. Because of that, we aim to analyze the role of Interleukin-6 at the train's model as an epigenetic and transgenerational factor to determine the sperm methylation pattern of wild type and IL-6 knockout mice.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES-SILVA, THAIS; FREITAS, GEANNE ARANTES; RODRIGUES HUNGARO, TALITA GUERREIRO; ARRUDA, ADRIANO CLEIS; OYAMA, LILA MISSAE; WERNECK AVELLAR, MARIA CHRISTINA; ARAUJO, RONALDO CARVALHO. Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice. SCIENTIFIC REPORTS, v. 11, n. 1, JUN 1 2021. (15/24399-5, 15/20082-7)