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Acute inflammatory response to moderate-intensity continuous and high-intensity interval training: role to toll-like receptor 4

Grant number: 18/17648-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): November 30, 2019
Effective date (End): November 29, 2020
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Fábio Santos de Lira
Grantee:Carolina Cabral Santos
Supervisor: Jonathan Peter Little
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Research place: University of British Columbia, Okanagan (UBC), Canada  
Associated to the scholarship:15/26148-0 - Role of toll like receptor 4 (TLR-4) in lipolytic response mediated by acute exhaustive exercise, BP.DR


In the present study, we aim to investigate the effects of short-term exercise (2 weeks) on the acute regulation of the expression of several cytokines that possess anti-inflammatory properties including interleukin-6 (IL-6) and interleukin-10 (IL-10) and the underlying mechanism involving signal transducer and activator of transcription protein (STAT3) and toll-like receptor 4 (TLR-4). Thirty inactive adults will be randomized to two groups of high-intensity interval exercise (HIIT) or moderate-intensity continuous training (MICT). To examine whether exercise is accompanied by inflammatory response and if the inflammation status is reversed by training adaptation, lipopolysaccharide (LPS)-induced tumour necrosis factor (TNF)-± production will be measured in whole blood cultures in the presence or absence of IL-6 or IL-10. Anti-inflammatory IL6/IL10 signalling and pro-inflammatory signalling through TLR-4 will be analysed by flow cytometry analysis. (AU)

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