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Role of toll like receptor 4 (TLR-4) in lipolytic response mediated by acute exhaustive exercise

Grant number: 15/26148-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2016
Effective date (End): June 01, 2021
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Fábio Santos de Lira
Grantee:Carolina Cabral Santos
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Associated scholarship(s):18/17648-7 - Acute inflammatory response to moderate-intensity continuous and high-intensity interval training: role to toll-like receptor 4, BE.EP.DR


The exhaustive exercise carried out continuously at moderate intensity, can affect on the rise in the concentrations of free fatty acids, mainly mediated by neuroendocrine response. Concomitant with this condition, it was postulated that fatty acids promote the activation of inflammatory response via receptors TLR type (Toll like receptor), specifically TLR-4 in different cell types, favoring the production of cytokines such as IL-6 and TNF -±. Additionally, it is speculated that activation of TLR-4 during exhaustive exercise can favor the process of lipolysis in adipose tissue thus increasing the availability of circulating fatty acids, however, this hypothesis has never been tested. Faced with this question, the objective of this project is to verify the TLR-4 ratio and the lipolysis process induced by exhaustive exercise. For this, the project will use two strains of animals: C57BL / 6J mice and knockout TLR-4 (TLR-4 - / -). For each animal strain will be formed 4 subgroups containing 10 animals each, as follows: group 1 sedentary control (C); 2 exhaustive exercise group with euthanasia immediately after exercise (EI); 3- exhaustive exercise 2 hours after exercise (E2); 4- 6 hours after exhaustive exercise exercise (E6). They will be assessed the metabolic profile (glucose, lactate and free fatty acids) and systemic inflammation, as well as activity of lipolytic enzymes in the mesenteric and retroperitoneal adipose tissue to determine the role of TLR-4. Experiments with knockout animals for TLR-4 will provide a better understanding of the role of TLR-4 in the process of lipolysis during exhaustive exercise. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, PAULA ALVES; FREITAS JUNIOR, ISMAEL FORTE; ZAGATTO, ALESSANDRO MOURA; JABUR RIBEIRO, JOSE PROCOPIO; CABRAL-SANTOS, CAROLINA; INOUE, DANIELA SAYURI; GEROSA-NETO, JOSE; LIRA, FABIO SANTOS. Acute effect of high-intensity interval training on metabolic and inflammatory markers in obese and overweight adolescents: Pilot study. European Journal of Inflammation, v. 17, SEP 2019. Web of Science Citations: 0.
CABRAL-SANTOS, CAROLINA; DE LIMA JUNIOR, EDSON ALVES; DA CRUZ FERNANDES, ISABELA MAIA; PINTO, RAFAEL ZAMBELLI; ROSA-NETO, JOSE CESAR; BISHOP, NICOLETTE CHARLLOTE; LIRA, FABIO SANTOS. Interleukin-10 responses from acute exercise in healthy subjects: A systematic review. Journal of Cellular Physiology, v. 234, n. 7, p. 9956-9965, JUL 2019. Web of Science Citations: 6.

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