Suturable vessel grafts from electrospun tubes for rapid vascularization of bone tissue engineered constructs

• Grant number: 16/04418-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: July 15, 2016
• End date: July 14, 2017
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Ana Maria Minarelli Gaspar
• Grantee: Caroline Faria Bellani
• Supervisor: Guy Schlatter
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Université de Strasbourg, France
• Associated to the scholarship: 14/17939-0 - Development of scaffolds of poly(caprolactone) incorporated with biosilicato and cellulose nanocristals for Bone Tissue Engineering, BP.DD

Abstract

Rapid vascularization of bone graft materials is a key step for early and long-term successful osteogenesis. Pre-vascularization of large constructs has great potential to improve functional vasculature throughout the scaffold to rapidly facilitate integration with the surrounding tissue and circumvent necrosis in the core of the scaffold. Engineered synthetic vessels obtained by electrospinning with fast degradation properties embedded in hydrogels may enable rapid remodeling into neo-artery. By the use of micropatterned collectors, it possible to control the vascular graft pore size in order to allow cell migration and neovascularization from the vascular graft. The aim of this research trainnee project is to develop a suturable vascular scaffold for use in rapid vascularization of grafts to heal critical size segmental bone defects. It is expected the fast-degrading micropatterned electruspun graft will stand the mechanical requirements for suture retention and vessel graft applications, and will assist cell migration and anamostosis between the vascular graft and the bone graft network. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FLAIG, FLORENCE; FARIA BELLANI, CAROLINE; UYUMAZ, OZGUN; SCHLATTER, GUY; HEBRAUD, ANNE. Elaboration and mechanical properties of elastomeric fibrous scaffolds based on crosslinked poly(glycerol sebacate) and cyclodextrin for soft tissue engineering. MATERIALS ADVANCES, v. 2, n. 4, p. 1284-1293, FEB 21 2021. (16/04418-8, 14/17939-0)

BELLANI, CAROLINE FARIA; YUE, KAN; FLAIG, FLORENCE; HEBRAUD, ANNE; RAY, PENGFEI; ANNABI, NASIM; SELISTRE DE ARAUJO, HELOISA SOBREIRO; BRANCIFORTI, MARCIA CRISTINA; MINARELLI GASPAR, ANA MARIA; SHIN, SU RYON; et al. Suturable elastomeric tubular grafts with patterned porosity for rapid vascularization of 3D constructs. BIOFABRICATION, v. 13, n. 3, JUL 2021. (16/04418-8, 14/17939-0)