Involvement of myosins in Dendritic cell-mediated trans-infection of HIV-1

• Grant number: 16/11679-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2016
• End date: June 30, 2018
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Bruna Cunha Gondim de Alencar
• Grantee: Taís Aparecida Matozo de Souza
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 14/23225-0 - Role of myosins in dendritic cell mediated trans-infection of HIV-1 and in HIV-1 replication in macrophages, AP.JP

Abstract

Trans-infection is a process through which uninfected dendritic cells (DCs) carry and transmit the virus HIV-1 to CD4 T cells. Several pieces of evidence point to an important role of the actin network in this process, but the motor proteins involved in trans-infection have not yet been described. This project intends to describe the myosins involved in HIV-1 trans-infection by DCs through RNAi-dependent gene silencing using primary human DCs. In addition, the project will determine the step of trans-infection at which one of these myosins participates, by using viral protein quantification and microscopy techniques. The identification of new host proteins involved in trans-infection may pave the way to the development of new treatments to control HIV-1 dissemination.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUZA, Taís Aparecida Matozo de. Involvement of myosins in HIV-1 trans-infection by dendritic cells. 2019. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.