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Evaluation of reproductive parameters of male rats exposed to sodium arsenite: a juvenile toxicity study

Grant number: 15/25821-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2016
Effective date (End): June 30, 2017
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Juliana Elaine Perobelli
Grantee:Paloma da Cunha de Medeiros
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Arsenic (As) is a metalloid found in organic and inorganic form. The more toxic is the inorganic form. Contaminated water and agricultural products, as well as contaminated sea food, are the main prospectors of intoxication. Little is known about the consequences of arsenic intake in the diet on the male reproductive system in pre-pubertal period. This study will investigate whether exposure to inorganic arsenic during male prepubertal development interferes with morphometric parameters of reproductive organs, as well as the dynamics of the spermatogenic process and endocrine receptors distribution in the epididymis, which could characterize future impairment on production and maturation of male gametes. Wistar male rats (21 days old) will receive water and rodent chow ad libitum. They will be divided into 3 groups (n = 10 for each experimental group): negative control, which will receive vehicle only (saline), As 1 group, that will receive the metalloid at 0.01 mg /L and As 2 group, which will receive metalloid at 10 mg /L. Arsenic will be administered in drinking water and the consumption will be measured on alternate days. With the results obtained in this study will be possible to understand whether the two arsenic levels administered during this important period of animal's development interfere with the maturation of the reproductive organs, as well as its morphophysiology.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAMELO, RICARDO R.; DE MEDEIROS, PALOMA DA CUNHA; DE CARVALHO CAVALCANTE, DEBORAH N.; ARANHA, MARIA L. G.; DUARTE, FABIO A.; DE CASTRO, ITALO B.; RIBEIRO, DANIEL A.; PEROBELLI, JULIANA E. Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats. ENVIRONMENTAL TOXICOLOGY, DEC 2019. Web of Science Citations: 0.
DE MEDEIROS, PALOMA DA CUNHA; SAMELO, RICARDO RODRIGUES; GOMES SILVA, ANA PRISCILA; ARAUJO SANTIAGO, MARCELLA DA SILVA; DUARTE, FABIO ANDREI; DE CASTRO, ITALO BRAGA; PEROBELLI, JULIANA ELAINE. Prepubertal exposure to low doses of sodium arsenite impairs spermatogenesis and epididymal histophysiology in rats. ENVIRONMENTAL TOXICOLOGY, v. 34, n. 1, p. 83-91, JAN 2019. Web of Science Citations: 6.

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