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Evaluation of the effects of the Klotho protein on the neuronal morphological alteration characteristics of the lack of PTEN protein

Grant number: 15/25491-2
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2016
Effective date (End): December 02, 2018
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Elisa Mitiko Kawamoto Iwashe
Grantee:Natalia Prudente de Mello
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/21308-8 - Evaluation of PTEN compartmentalization on neurogenesis and synaptic plasticity influenced by environmental factors, AP.JP
Associated scholarship(s):17/25279-9 - Developing new tools to study the relationship between PTEN and Klotho expression by molecular biological approaches, BE.EP.MS


Previous data indicate that the lack of PTEN protein leads to morphological alterations, which generate dysfunction in the neuronal development that commits its normal function. Understanding these mechanisms and the pathways to reverse or retard this process can result in benefits in the treatment and prevention of diseases related to the Central Nervous System (CNS).PTEN (Phosphatase and tensin homolog on chromosome ten) is a tumor suppressor protein that is related to growth, proliferation and cellular survival. PTEN's deletion leads to alteration in the number, size and migration of the cells resulting in hypertrophic dendrites and increased ramifications. Based on studies that showed the potential of the klotho protein to reverse or retard stem cell, this project aims to study the possible effects of the klotho in PTEN deleted neurons in revert the morphological alterations generated by the lack of PTEN and the likely signaling pathway involved in this morphological modulation.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CABRAL-COSTA, J. V.; ANDREOTTI, D. Z.; MELLO, N. P.; SCAVONE, C.; CAMANDOLA, S.; KAWAMOTO, E. M. Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice. SCIENTIFIC REPORTS, v. 8, JUN 5 2018. Web of Science Citations: 1.

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