Bioenergetic study of Trypanosoma Cruzi isolates in patients with different clinical forms of Chagas Disease

• Grant number: 16/09112-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2016
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Fernanda Ramos Gadelha
• Grantee: Isabella Bagni Nakamura
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Chagas disease (CD) has distincts clinical manifestations, which varies among individuals and geographical regions. The geographical heterogenity of CD suggests that the genetic variation of the host, the parasite, or both, are relevant for the establishment of the clinical form of the disease. The diversity that exists among Trypanosoma cruzi strains has been the Aquiles's heel for the development of a more specific therapy, and as so, less toxic to the vertebrate host. Taking this into account, the purpose of this project is to establish a comparative analysis of the proliferation rates and mitochondrial bioenergetics of T. cruzi isolates from CD patients with distinct clinical forms of the disease, i.e. indeterminate, cardiac, digestive and cardiodigestive. These results will allow to establish a correlation between the biochemical parameters of the parasites and the different clinical forms of the disease. The development of this project will bring important data to a better understanding of the patogenesis of CD.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NAKAMURA, ISABELLA BAGNI; MIGUEL, DANILO CICCONE; BRUSCATO, ANDRESSA; PEREIRA, MARIANE BARROSO; CAMPIOLO, DIMAS; DE ALMEIDA, EROS ANTONIO; PELOSO, EDUARDO DE FIGUEIREDO; GADELHA, FERNANDA RAMOS. Biological characterization of Trypanosoma cruzi epimastigotes derived from trypomastigotes isolated from Brazilian chagasic patients. CURRENT RESEARCH IN MICROBIAL SCIENCES, v. 3, p. 7-pg., 2022-01-01. (16/09112-4, 15/24595-9)