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The effect of L-carnitine in contrast-induced nephropathy in diabetic rats

Grant number: 16/06302-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Nursing - Medical-Surgical Nursing
Principal researcher:Cassiane Dezoti da Fonseca
Grantee:Natalia Abreu de Oliveira
Home Institution: Escola de Enfermagem (EE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Contrast-induced nephropathy (CIN) is a reduction of renal function resulting of iodinated contrast (IC) use. CIN is considered the third cause of hospital-acquired acute kidney Injury (AKI). Chronic hyperglycemia state on diabetes mellitus results in a vulnerable kidney to hypoxia and oxidative stress. Diabetes Mellitus is an important risk factor to development of CIN. L-carnitine is a compound lipid metabolism and antioxidant effect is one of its major mechanisms of action. However, it is unknown whether or not L-carnitine is effective in treating CIN. The aim of this study will be to evaluate the L-carnitine effect on CIN in diabetic rats. Adult male Wistar rats weighing 250-290g will used and divided into five groups: Citrate, Diabetes Mellitus (DM), Diabetes + iodinated contrast (DM+IC), L-carnitina (L-Car) and DM + IC + L-Car. Physiological parameters (Body weight, water and food intake, glicemia and kideny weight and body weight ratio); Renal function (Inulin Clearance); hemodynamics (arterial blood pressure; renal blood flow; renal vascular resistance)and oxidative profile (urinary peroxides, urinary TBARS, thiois in renal tissue and urinary nitric oxide) will evaluated.