| Grant number: | 16/07866-1 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | August 01, 2016 |
| End date: | December 31, 2017 |
| Field of knowledge: | Biological Sciences - Pharmacology - Ethnopharmacology |
| Principal Investigator: | José Roberto Bosqueiro |
| Grantee: | Henrique Jorge Novaes Morgan |
| Host Institution: | Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil |
Abstract Cancer is a high incidence worldwide disease. Cachexia, a multifactorial metabolic syndrome that affects at least 50% of patients, leads to a progressive functional impairment, contributing significantly to a worse quality of life and high mortality. The solid Ehrlich carcinoma is a transplantable tumor model which leads to the development of the cachectic syndrome. The use of medicinal plants is practiced since the beginning of humanity and has observed a sharp growth in recent years. Government programs encourage and distribute medicines derived from plants by the public health system. The present study aims to investigate the effects of administration of butanolic fraction of the methanolic extract of Vochisia tucanorum Mart. in cachectic solid Ehrlich carcinoma-bearing mice in the search for an alternative for the treatment of cachexia associated with cancer by having compounds such as flavonoids and triterpenes with antineoplastic, anti-inflammatory and antioxidant activity. It was observed in initial experiments, a significant reduction in tumor weight after treatment with the extract for 14 days from the tumor implantation. To assess the possible action of the extract, it will be quantified serum levels of triglyceride, albumin, total protein, total and HDL cholesterol by commercial kits, muscle and liver glycogen, blood glucose, food and water ingestion and body weights, as well as glucose tolerance and insulin sensitivity by ipGTT and ipITT. Furthermore, the action on tumor growth will be assessed by the expression of PCNA and caspase-3 proteins in the tumor by Western blotting. The results will be expressed as mean ± standard error of the mean. For multiple comparison results will be used parametric ANOVA - one way, followed by post Tukey test. For comparisons between two groups the Student's t test is applied. The adopted significance level will be p <0.05. | |
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