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Testicular morphofunctional effects of adjuvant induced arthritis (AIA) in wistar rats

Grant number: 16/10100-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Maria Angélica Spadella
Grantee:Ana Cristina Assumpção Benjamin
Home Institution: Faculdade de Medicina de Marília (FAMEMA). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Marília , SP, Brazil

Abstract

Rheumatoid arthritis (RA) is a disease characterized by an inflammatory disorder that mainly involves the synovial membrane of joints. It affects 0.5 to 1% of the adult population, especially women in a proportion of 3:1. Although the articular manifestations are most common in RA, there are many extra-articular manifestations which take part in the development of this disease, some of which are quite elucidated in the literature. In addition to rheumatoid nodules, cardiovascular disease, lung disease, among others, studies suggest that rheumatoid arthritis can affect the male gonads. Being the male population less affected by the disease, few studies that address this group of patients were developed. However, studies of this nature are important in improving the care provided to male patients. In some studies, it was observed reduction of testicular androgen production and consequent reduction of the serum level of this hormone. It was also found that inflammatory cytokine produced by macrophages, systemically abundant in RA, may have negative influence on gonadal testosterone production. One of the widely used animal models of arthritis is the adjuvant-induced arthritis (AIA). Testicular dysfunction consistent with those observed in male patients with RA could also be observed in this animal model. Therefore, it is proposed a further evaluation of the organs that composes the male reproductive system in order to better understand the manifestations of RA in these organs.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, C. R.; BENJAMIN, A. C. A.; CHIES, A. B.; DOMENICONI, R. F.; ZOCHIO, G. P.; SPADELLA, M. A. Adjuvant-induced arthritis affects testes and ventral prostate of Wistar rats. ANDROLOGY, AUG 2019. Web of Science Citations: 0.

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