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Axonal regenerative potential of GM-CSF in C57BL/6 mouse peripheral nerve

Grant number: 16/03094-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Biological Sciences - Immunology
Principal researcher:André Luis Bombeiro
Grantee:Bruna Toledo Nunes Pereira
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Peripheral nerve injury leads to disruption of the nerve and interruption of impulse transmission. However, if the perineurium surrounding the lesion is preserved, axonal regeneration following degeneration of the distal stump, a process named Wallerian degeneration, is possible. Participation of Schwann cells in myelin debris removal is an important step because axonal growth inhibitors are found in myelin. Additionally, tissue clearance is largely improved by macrophages and other infiltrating immune cells. In view of the role of the immune system in nerve regenerative process, we will boost the immune response by administrating the granulocyte and macrophage colony stimulating factor (GM-CSF) in mice that were previously submitted to sciatic nerve crushing. In this way, we aim at increasing production and influx of monocytes in the lesion area and thus accelerate the regenerative process. By histological approaches, we will evaluate the presence of macrophages in the nerve as well as its current regenerative stage, via axonal markers and growth associated protein imunolabelling. Motor recovery will also be followed up. We believe that this study will bring new perspectives regarding immune system interventions in the peripheral nerve regenerative process.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOMBEIRO, ANDRE LUIS; NUNES PEREIRA, BRUNA TOLEDO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE. Granulocyte-macrophage colony-stimulating factor improves mouse peripheral nerve regeneration following sciatic nerve crush. European Journal of Neuroscience, v. 48, n. 5, p. 2152-2164, SEP 2018. Web of Science Citations: 1.

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