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Identification and characterization of new viral genomes in non-human New World primates

Grant number: 16/13171-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): February 28, 2018
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Leila Sabrina Ullmann
Grantee:Paula Cristian Cardoso
Home Institution: Instituto de Biotecnologia (IBTEC). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Due the wide diversity of animal species they become source of various infectious diseases, generating currently a great concern to global health security, which viruses are the main causes. Many of the emerging viruses are RNA, because of your high mutation rate capacity they can adapt to their new host, causing the transmission between animal and human interactions, through direct contact with an animal, or indirectly through exposure to urine or faeces of infected animals or even by human to human contact, resulting in a pandemic, such as influenza H1N1 in 2009 and more recently Ebola. The closest relatives of humans, non-human primates (NHP), are important zoonotic agents holders of 20% of the diseases that affect humans, and they contribute as experimental models because of their evolutionary proximity. Methods have been developed worldwide to aid in the diagnosis of these new diseases and later to combat them, techniques have been used through the metagenomic for detection of new viral agents. The currently study aims identification, characterization and standardization of molecular biology techniques to identify new viral agents discovered by massive sequencing in PNH plasma samples for further study of the prevalence of viral genomes found.