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EVALUATION OF GLOBAL PROFILE OF DNA METHYLATION IN KIDNEY DONORS BASED ON EXPANDED CRITERIA DONORS

Grant number: 16/08301-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Mario Abbud Filho
Grantee:Naiane Do Nascimento Gonçalves
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

The insufficient number of organs to attend the high numbers of patients into the waiting list is one of the most problems of kidney transplant (Tx), consequently increases the cost of the treatment, decreases the quality of life and high mortality rates. Therefore, the transplant centers have started to develop some alternatives for the organ allocation, in addition to the use of kidneys from someone who is dead, so they started to use a different criteria of the traditional "pattern", the standard criteria donors (SCD), that why is called kidneys from expanded criteria donors (ECD). The use of ECD is associated with lower quality of the organs and hence generates high rates of discard of theses organs. Clinical and histological analysis as tools to assess and predict the outcomes of ideal organs of ECD, have conflicting results. DNA methylation is an epigenetic mechanism most studied and well understood, catalyzed by the enzymes of the family of DNA methyltransferases, especially DNMT1, DNMT3A and DNMT3B. Epigenetics events that occur in kidney transplantation profile can be a useful tool to try to study the outcomes associated with ECD. Thus, the aim of this study is to determine the overall methylation profile of the DNA and the DNMTs expression levels in the pre transplant biopsies (T0) of the ECD kidneys and the impact of late funtion of renal graft. In this context, the proposal of using DNA methylation as a tool to determine the quality of kidney of the donors whose is already dead can increase the supply of organs for Tx and also the survival rate of these organs, as a result cost reduction.

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