| Grant number: | 16/14584-2 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | December 01, 2016 |
| End date: | November 30, 2017 |
| Field of knowledge: | Health Sciences - Dentistry - Periodontology |
| Principal Investigator: | Sérgio Luís Scombatti de Souza |
| Grantee: | Paula Gabriela Faciola Pessoa de Oliveira |
| Supervisor: | Paulo Guilherme Gonçaalves Gomes Coelho |
| Host Institution: | Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Institution abroad: | New York University, United States |
| Associated to the scholarship: | 15/09879-0 - Evaluation of a new hydroxiapatite covered nanometric implant surface. An in vitro study in rats, BP.DR |
Abstract Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action, or both. The high prevalence of periodontitis and tooth loss in diabetic subjects represents an important health implication, and treatment with dental implants is considered a therapeutic strategy for replacing lost teeth in these patients. Diabetes has been considered a risky condition for dental implants, as it is associated to delayed wound healing, prevalence of microvascular disease and impaired response to infection. The microstructure and surface characteristics of dental implants have a direct influence on bone response, because they can affect protein adsorption and modulate cell proliferation and differentiation. Surface characteristics such as roughness, chemistry and energy have been reported to significantly influence cell differentiation, protein production and, consequently, bone growth and osseointegration. Thus, taking into account the development of new implant surfaces with processes aimed at qualitative and quantitative improvement of osseointegration phenomenon, and on the other hand the healing deficiency of DM, which can be used as models of subjects with impaired bone repair. The aim of this in vivo study is to evaluate the nanomechanical response of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite through nanoindentation test. The results are expressed as mean ± standard deviation of the groups in each period, considering the animal as experimental unit. Pre-tests will be performed to assess the normality of the data. Based on the results, the appropriate statistical tests to analyze differences between groups will be selected in each period (7 and 30 days), and intra-group, in relation to different times. In all analyzes, will be considered p <0.05. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |