Expression of the GABA-A alpha 5 receptor in the hippocampus of animals treated with standardized extract of Ginkgo biloba in the extinction of fear conditioning

• Grant number: 16/12179-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): September 01, 2016
• Effective date (End): August 31, 2017
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Suzete Maria Cerutti
• Grantee: Danilo Dias da Silva
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

The actions of standardized extract of Ginkgo biloba (EGb) the improvement of memory has been demonstrated by our group from data which showed that conditioned suppression resulted in increased expression of CREB-1 (mRNA and protein) in the dorsal hippocampus of rats. Understanding these effects is needed for studies on the molecular mechanisms associated with this modification. Several studies have suggested that glutamatergic, GABAergic and serotonergic transmission are involved in memory formation and thus may be targets of modulatory effects observed for EGb. Thus, this study aims to analyze the expression of GABA receptor GABAA type alpha subunit 5 in the dorsal hippocampus of rats subjected to extinction of conditioned emotional response as well as in groups submitted to treatment with antagonists and agonists of the aforementioned routes. It is expected that the results allow hypotheses modulation of pathways analyzed the effects of the extract in the region studied. (AU)