Corelation between neck circunference and metabolic profile of women with polycystic ovary syndrome

• Grant number: 16/05391-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2016
• End date: August 31, 2017
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: José Mendes Aldrighi
• Grantee: Milena Martello Cristófalo
• Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil

Abstract

Polycystic ovary syndrome (PCOS) is a prevalent anovulation disorder of reproductive age. Frequently, women diagnosed with PCOS present menstrual irregularity, hyperandrogenism and multifollicular aspect of ovarian morphology. Nevertheless, metabolic changes are common in these patients, which include hyperinsulinemia, insulin resistance (IR), metabolic syndrome, obesity, lipid abnormalities, predisposition to type 2 diabetes mellitus (DM II) and cardiovascular disease (CVD). Anthropometric data are essential in the assessment of women with PCOS, since it is well established that weight excess has also deleterious effect on the metabolic profile. Among the anthropometric tests, the circumference of the neck (CP) is underused, although effective to indicate insulin resistance and cardiovascular risk in patients not necessarily diagnosed with the syndrome. The literary registry of the association between CP and metabolic profile of patients with PCOS is important, therefore, to investigate the characteristics specifically in the population affected by the disease, as well as to encourage the use of CP. To this purpose, the current cross-sectional study will evaluate women with and without PCOS for anthropometric tests and collect laboratory data on the metabolic profile, including blood glucose, triglycerides, HDL cholesterol, LDL cholesterol and VLDL cholesterol.