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Correlation among radiographic density - RD, DXA, structure and bone strength: study in vitro

Grant number: 16/13647-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal researcher:Wagner André Pedro
Grantee:Joyce de Jesus Farias
Home Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Osteoporosis is a disease that can reach all bones of the body, weakening them structure, Bone Mineral Density (BMD) and microarchitecture and thus increasing the possibility of fracturing upon exertion. For the evaluation of BMD numerous methodologies have been developed, however, their costs are still high and incompatible with the reality of most countries, including Brazil. The Radiographic Densitometry - RD is the technique that measures the degree of blackening of a radiographic film, photographic or digital and is used for sequential analysis of bone variations, with significantly lower cost than other methodologies, good precision and accuracy. This study aims to determine the mathematical correlation - Transfer function - between densitometry techniques, DXA (elected as the "Gold Standard") and RD, aiming to improve the BMD service. For this, the diaphysis bone samples are used (10) and proximal epiphysis (10) of the tibia of a bovine (Bos taurus) healthy. It will also be analyzed bone strength by destructive mechanical compression.