Comparative phylogeography of plants in the Central Amazonia
| Grant number: | 16/14423-9 |
| Support type: | Scholarships abroad - Research Internship - Post-doctor |
| Effective date (Start): | February 05, 2017 |
| Effective date (End): | November 04, 2017 |
| Field of knowledge: | Biological Sciences - Genetics |
| Principal Investigator: | Fernando Cendes |
| Grantee: | Rodrigo Secolin |
| Supervisor abroad: | David Comas |
| Home Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Local de pesquisa : | Universitat Pompeu Fabra (UPF), Spain |
| Associated to the scholarship: | 13/19524-0 - Genetic association studies in mesial temporal lobe epilepsy and stroke, BP.PD |
Abstract Population structure and ancestry estimation have been successfully used in order to take population differences into account in association studies. However, it is necessary to have good ancestry knowledge of the population under investigation. Previous studies have evaluated population structure and ancestry in Brazilian individuals. However, most of them were limited by i) the number of individuals analyzed, ii) by the small number of polymorphic markers studies, and iii) were not representative of important regions in Brazil, such as the state of São Paulo. We have generated genotype data from high-density single nucleotide polymorphism (SNP)- arrays, whole genome sequencing (WES), and copy number variations (CNVs), available from the same cohort. Therefore, by the integration of these data, we aim to analyze population structure and ancestry of 350 unrelated reference individuals and 350 individuals with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLEHS) which were assessed at UNICAMP university hospital. In addition, we will perform additional types of analyses in the MTLEHS cohort in order to improve our chances of identifying susceptibility locus(ci) for the disease. We believe that this study can reveal new and relevant information about population ancestry and fine genetic structure, which will be crucial not only to our own studies but also to genetic association studies currently being performed in cohorts originating from the state of São Paulo. | |