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Possible association between psychophysiological stress and Parkinson's Disease in a model of parkinsonism induced by reserpine

Grant number: 16/13506-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Regina Helena da Silva
Grantee:Laura Faria de Moraes Olivatto
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Parkinson's disease (PD), a chronic progressive neurodegenerative disorder, is associated with degeneration of dopaminergic neurons in substantia nigra pars compacta and striatum. In addition, several studies speculate that oxidative stress take part in reduction of dopamine levels.Although some cases of the disease can be attributed to genetic and environmental influences, the cause of most of the cases is still unknown. Chronic psychophysiological stress as a predisposing factor for Parkinson's disease is still poorly studied, but the hypothesis is corroborated by many clinical and laboratory indications. Hence, this study aims to investigate the correlation between a previous exposition to a chronic mild stress protocol and the onset of parkinsonism signs in Wistar rats repeatedly treated with a low dose of reserpine.