Pharmacokinetics of efavirenz administered in the form of inorganic nanoparticles in rabbits.

• Grant number: 15/23843-9
• Support type: Scholarships in Brazil - Master
• Effective date (Start): November 01, 2016
• Effective date (End): February 28, 2018
• Field of knowledge: Health Sciences - Pharmacy - Medicines Analysis and Control
• Principal Investigator: Rosangela Gonçalves Peccinini
• Grantee: Evelin dos Santos Martins
• Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) commonly used on the treatment of Acquired Immunodeficiency Syndrome (AIDS) due its potent antiviral activity and clinical effectiveness when combined with two nucleoside reverse transcriptase inhibitors (NRTI) in the first line antiretroviral therapy (ART). Efavirenz is classified as class II in the Biopharmaceutics Classification System (BCS) and its oral bioavailability (Foral) in humans has a variable profile among individuals as a result of the influence of many factors, for instance, aqueous solubility and dissolution rate. The pharmaceutical technology offers many strategies which allows to optimize the dissolution rate and to increase bioavailability such as the use of functional excipients in inorganic nanoparticle, thereby reducing the dose and frequency of administrations and reducing the risk of side effects. This work focus on the evaluation and on the comparison of the pharmacokinetics of EFV transported through a inorganic nanoparticle, developed by Fontes and his team in the Federal University of Pernambuco, in relation to the free drug.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, EVELIN DOS SANTOS; OLIVEIRA, JONATA AUGUSTO; FRANCHIN, TAISA BUSARANHO; ULIAN SILVA, BRUNA CRISTINA; CANDIDO, CAROLINE DAMICO; PECCININI, ROSANGELA GONCALVES. Simple and Rapid Method by Ultra High-Performance Liquid Chromatography (UHPLC) with Ultraviolet Detection for Determination of Efavirenz in Plasma: Application in a Preclinical Pharmacokinetic Study. Journal of Chromatographic Science, v. 57, n. 10, p. 874-880, NOV 2019. Web of Science Citations: 0.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARTINS, Evelin dos Santos. Farmacocinética do efavirenz administrado na forma de micropartículas inorgânicas em coelhos. 2018. 106 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas..