Bioinspired gene delivery optimization of nanoparticles in retinal pigmented epithelium model

• Grant number: 16/16259-1
• Support type: Scholarships in Brazil - Master
• Effective date (Start): December 01, 2016
• Effective date (End): February 28, 2018
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Marcelo Bispo de Jesus
• Grantee: Guilherme Capiraço Campese
• Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/03002-7 - Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile, AP.JP

Abstract

With increasing life expectancy on a global scale, there is an urgency in the study and development of devices capable of treating chronic eye diseases that already have a frequency of occurrence greater than eye diseases of infectious nature. We aim the production and characterization of cationic SLN bioinspired in the visual cycle in order to carry bioactive compounds to cells in retinal pigmented epithelium (RPE), and subsequent elucidation of molecular mechanisms of internalization, intracellular trafficking and increased transfection efficiency.