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Bioinspired gene delivery optimization of nanoparticles in retinal pigmented epithelium model

Grant number: 16/16259-1
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2016
Effective date (End): February 28, 2018
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Marcelo Bispo de Jesus
Grantee:Guilherme Capiraço Campese
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:14/03002-7 - Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile, AP.JP

Abstract

With increasing life expectancy on a global scale, there is an urgency in the study and development of devices capable of treating chronic eye diseases that already have a frequency of occurrence greater than eye diseases of infectious nature. We aim the production and characterization of cationic SLN bioinspired in the visual cycle in order to carry bioactive compounds to cells in retinal pigmented epithelium (RPE), and subsequent elucidation of molecular mechanisms of internalization, intracellular trafficking and increased transfection efficiency.