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Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile

Abstract

Nanomedicine is presented as a new technology to assist in the treatment and diagnosis of various diseases. However, this new technology brings new challenges, not only in developing new nanodevices, as well as in the interaction of these nanomaterials with biological environment. Understanding the molecular mechanisms involved in the internalization and processing of nanoparticles by eukaryotic cells is vital to develop more efficient and safer nanoparticles. Although the more internalization pathways lead to degradation of internalized material, increasing evidence in the literature suggest that some nanomaterials are biopersistent, thus leading to negative impact on cellular metabolism. Thereby, recently, a new area of knowledge has been established, the nanotoxicology. This project aims to study how the internalization and intracellular trafficking of nanoparticles affects their biological role, e.g. genes delivery, as well as evaluating the adverse effects caused by these nanomaterials at the cellular level. (AU)

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BANDEIRA FERREIRA, LUIZ ALBERTO; GARCIA-FOSSA, FERNANDA; RADAIC, ALLAN; DURAN, NELSON; FAVARO, WAGNER JOSE; DE JESUS, MARCELO BISPO. Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 151, p. 162-170, . (15/06134-4, 14/03002-7)
PADILHA MENDONCA, MONIQUE CULTURATO; FERREIRA, LUIZ BANDEIRA; RIZOLI, CINTIA; BATISTA, ANGELA GIOVANA; MAROSTICA JUNIOR, MARIO ROBERTO; DA SILVA, EMANUELI DO NASCIMENTO; CADORE, SOLANGE; DURAN, NELSON; DA CRUZ-HOFLING, MARIA ALICE; DE JESUS, MARCELO BISPO. N-Acetylcysteine reverses silver nanoparticle intoxication in rats. Nanotoxicology, v. 13, n. 3, p. 326-338, . (14/03002-7, 16/03765-6, 15/06134-4)
MENDONCA, MONIQUE C. P.; RODRIGUES, NATALIA P.; DE JESUS, MARCELO B.; AMORIM, MONICA J. B.. Graphene-Based Nanomaterials in Soil: Ecotoxicity Assessment Using Enchytraeus crypticus Reduced Full Life Cycle. NANOMATERIALS, v. 9, n. 6, . (14/03002-7, 17/18867-1)
DOS REIS, SAMARA BONESSO; SILVA, JULIANA DE OLIVEIRA; GARCIA-FOSSA, FERNANDA; LEITE, ELAINE AMARAL; MALACHIAS, ANGELO; POUND-LANA, GWENAELLE; FURTADO MOSQUEIRA, VANESSA CARLA; OLIVEIRA, MONICA CRISTINA; BRANCO DE BARROS, ANDRE LUIS; DE JESUS, MARCELO BISPO. Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes. BIOMEDICINE & PHARMACOTHERAPY, v. 134, . (14/03002-7, 15/06134-4)
MENDONCA, MONIQUE C. P.; RODRIGUES, NATALIA P.; SCOTT-FORDSMAND, JANECK J.; DE JESUS, MARCELO BISPO; AMORIM, MONICA J. B.. The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus. Environmental Pollution, v. 256, . (14/03002-7, 17/18867-1)
FERREIRA, LUIZ A. B.; DOS REIS, SAMARA BONESSO; DA SILVA, EMANUELI DO NASCIMENTO; CADORE, SOLANGE; BERNARDES, JULIANA DA SILVA; DURAN, NELSON; DE JESUS, MARCELO B.. Thiol-antioxidants interfere with assessing silver nanoparticle cytotoxicity. Nanomedicine-Nanotechnology Biology and Medicine, v. 24, . (15/06134-4, 14/03002-7)
MENDONCA, MONIQUE C. P.; RIZOLI, CINTIA; AVILA, DAIANA S.; AMORIM, MONICA J. B.; DE JESUS, MARCELO B.. Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing. FRONTIERS IN ENVIRONMENTAL SCIENCE, v. 5, . (14/03002-7, 16/03765-6)
BANDEIRA FERREIRA, LUIZ ALBERTO; GARCIA-FOSSA, FERNANDA; RADAIC, ALLAN; DURAN, NELSON; FAVARO, WAGNER JOSE; DE JESUS, MARCELO BISPO. Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 151, p. 9-pg., . (15/06134-4, 14/03002-7)
SAMPAIO BONAFE, CARLOS FRANCISCO; CONCEICAO BISPO, JOSE AILTON; DE JESUS, MARCELO BISPO. The Polygonal Model: A Simple Representation of Biomolecules as a Tool for Teaching Metabolism. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, v. 46, n. 1, p. 66-75, . (14/03002-7)
BECHER, TIAGO B.; MENDONCA, MONIQUE C. P.; DE FARIAS, MARCELO A.; PORTUGAL, V, RODRIGO; DE JESUS, MARCELO B.; ORNELAS, CATIA. Soft Nanohydrogels Based on Laponite Nanodiscs: A Versatile Drug Delivery Platform for Theranostics and Drug Cocktails. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 26, p. 21891-21900, . (16/03765-6, 13/11519-7, 14/03002-7, 18/02093-0)
ALLAN RADAIC; GUSTAVO OLIVEIRA PUGLIESE; GUILHERME CAPIRAÇO CAMPESE; FRANCISCO BENEDITO TEIXEIRA PESSINE; MARCELO BISPO DE JESUS. COMO ESTUDAR INTERAÇÕES ENTRE NANOPARTÍCULAS E SISTEMAS BIOLÓGICOS. Química Nova, v. 39, n. 10, p. 1236-1244, . (13/05432-6, 14/03002-7)
GUILHERME, VIVIANE A.; RIBEIRO, LIGIA N. M.; TOFOLI, GIOVANA RADOMILLE; FRANZ-MONTAN, MICHELLE; DE PAULA, ENEIDA; DE JESUS, MARCELO BISPO. Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye. CURRENT PHARMACEUTICAL DESIGN, v. 23, n. 43, p. 6659-6675, . (14/03002-7, 14/14457-5)
FACHI, JOSE LUIS; FELIPE, JAQUELINE DE SOUZA; PRAL, LAIS PASSARIELLO; DA SILVA, BRUNA KARADI; CORREA, RENAN OLIVEIRA; PEREIRA DE ANDRADE, MIRELLA CRISTINY; DA FONSECA, DENISE MORAIS; BASSO, PAULO JOSE; SARAIVA CAMARA, NIELS OLSEN; DE SALES E SOUZA, ERICKA LORENNA; et al. Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. CELL REPORTS, v. 27, n. 3, p. 750+, . (17/01451-7, 12/10653-9, 16/23142-3, 13/06810-4, 14/03002-7, 15/01507-7, 18/01753-6, 15/06134-4, 17/25679-7, 17/06577-9, 18/02208-1, 17/26366-2, 17/16280-3)
GARCIA-FOSSA, FERNANDA; GAAL, VLADIMIR; DE JESUS, MARCELO BISPO. PyScratch: An ease of use tool for analysis of scratch assays. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 193, . (14/03002-7, 15/06134-4)
MENDONCA, M. C. P.; RADAIC, A.; FOSSA, F. G.; CRUZ-HOFLING, M. A.; DE JESUS, M. B.; IOP. Toxicity of cationic solid lipid nanoparticles in rats. WAKE CONFERENCE 2021, v. 1323, p. 6-pg., . (14/03002-7, 16/03765-6)

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Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS BIOSSINTÉTLCAS DE PRATA, NANOPARTÍCULAS BIOSINTÉTLCAS DE PRATA OBTIDAS E SEU USO BR1020170181294 - Universidade Estadual de Campinas (UNICAMP) . Marcelo Bispo de Jesus ; Patrick Vianna Garcia ; Wagner José Fávaro ; Luiz Alberto Bandeira Ferreira ; Nelson Eduardo Duran Caballero - August 2017, 24

(EN) PROCESS FOR PRODUCING SILVER BIOSYNTHETIC NANOPARTICLES, THE SILVER BIOSYNTHETIC NANOPARTICLES PRODUCED AND USE THEREOF PCT/BR2018/000050 - Universidade Estadual de Campinas (UNICAMP) . FAVARO, Wagner José ; FERREIRA, Luiz Alberto Bandeira ; GARCIA, Patrick Vianna ; DE JESUS, Marcelo Bispo ; CABALLERO, Nelson Eduardo Duran - August 2018, 24