| Full text | |
| Author(s): Show less - |
Fachi, Jose Luis
[1]
;
Felipe, Jaqueline de Souza
[1]
;
Pral, Lais Passariello
[1]
;
da Silva, Bruna Karadi
[1]
;
Correa, Renan Oliveira
[1]
;
Pereira de Andrade, Mirella Cristiny
[1]
;
da Fonseca, Denise Morais
[2]
;
Basso, Paulo Jose
[2]
;
Saraiva Camara, Niels Olsen
[2]
;
de Sales e Souza, Ericka Lorenna
[3]
;
Martins, Flaviano dos Santos
[3]
;
Sato Guima, Suzana Eiko
[4]
;
Thomas, Andrew Maltez
[4]
;
Setubal, Joao Carlos
[4, 5]
;
Magalhaes, Yuli Thamires
[4]
;
Forti, Fabio Luis
[4]
;
Candreva, Thamiris
[6]
;
Rodrigues, Hosana Gomes
[6]
;
de Jesus, Marcelo Bispo
[7]
;
Consonni, Silvio Roberto
[8]
;
Farias, Alessandro dos Santos
[9]
;
Varga-Weisz, Patrick
[10, 11]
;
Ramirez Vinolo, Marco Aurelio
[1]
Total Authors: 23
|
| Affiliation: Show less - | [1] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunoinflammat, BR-13083862 Campinas, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Lab Biotherapeut Agents, BR-31270901 Belo Horizonte, MG - Brazil
[4] Univ Sao Paulo, Inst Chem, Dept Biochem, BR-05508000 Sao Paulo, SP - Brazil
[5] Virginia Polytech Inst & State Univ, Biocomplex Inst, Blacksburg, VA 24061 - USA
[6] Univ Estadual Campinas, Sch Appl Sci, Lab Nutrients & Tissue Repair, BR-13484350 Limeira, SP - Brazil
[7] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Nanocell Interact Lab, BR-13083862 Campinas, SP - Brazil
[8] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Citochem & Immunocitochem, BR-13083862 Campinas, SP - Brazil
[9] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Neuroimmunol, BR-13083862 Campinas, SP - Brazil
[10] Univ Essex, Sch Biol Sci, Colchester CO4 3SQ, Essex - England
[11] Babraham Inst, Nucl Dynam Programme, Cambridge CB22 3AT - England
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | CELL REPORTS; v. 27, n. 3, p. 750+, APR 16 2019. |
| Web of Science Citations: | 3 |
| Abstract | |
Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced colitis. Butyrate has no effect on C. difficile colonization or toxin production. However, it attenuates intestinal inflammation and improves intestinal barrier function in infected mice, as shown by reduced intestinal epithelial permeability and bacterial translocation, effects associated with the increased expression of components of intestinal epithelial cell tight junctions. Activation of the transcription factor HIF-1 in intestinal epithelial cells exerts a protective effect in C. difficile-induced colitis, and it is required for butyrate effects. We conclude that butyrate protects intestinal epithelial cells from damage caused by C. difficile toxins via the stabilization of HIF-1, mitigating local inflammatory response and systemic consequences of the infection. (AU) | |
| FAPESP's process: | 17/01451-7 - Investigating Rho GTPases pathways in the response of glioma cell lines to genotoxic stress |
| Grantee: | Yuli Thamires Magalhães |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 12/10653-9 - Role of short chain fatty acids and their receptor (GPR43) in the immune response to anaerobic bacteria in vivo and in vitro |
| Grantee: | Marco Aurélio Ramirez Vinolo |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/23142-3 - Interaction between HIF-1 and short-chain fatty acids in the intestine: what is the role of HIF-1 acetylation? |
| Grantee: | Renan Oliveira Corrêa |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/06810-4 - Mechanisms of action of omega-3 and omega-6 in the tissue repair process: neuro-immune focus |
| Grantee: | Hosana Gomes Rodrigues |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/03002-7 - Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile |
| Grantee: | Marcelo Bispo de Jesus |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/01507-7 - Microbial community profiling of human cancers |
| Grantee: | Andrew Maltez Thomas |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/01753-6 - Identification and functional investigation of proteins that interact with Cdc42 and DUSP12 enzymes in human cells under conditions of genomic instability: a proteomic approach |
| Grantee: | Fábio Luis Forti |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/06134-4 - Multi-User Equipment approved in grant 2014/03002-7: cell imaging multi-mode reader |
| Grantee: | Marcelo Bispo de Jesus |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 17/25679-7 - Effects of short-chain fatty acids and their receptor FFAR2 on the development of periodontitis in an experimental model |
| Grantee: | Bruna Karadi da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/06577-9 - Mechanisms involved in the protective effect of short-chain fatty acids against Clostridium difficile-associated colitis |
| Grantee: | José Luís Fachi |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/02208-1 - Effect of short chain fatty acids on the function of type 3 innate lymphoid cells: involvement of the FFAR2 receptor in this process |
| Grantee: | Laís Passariello Pral |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/26366-2 - Influence of the inflammatory response on the extracellular matrix composition during the wound healing in FAT-1 mice |
| Grantee: | Thamiris Candreva Robles |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/16280-3 - Role of the interaction between HIF-1 and the short chain fatty acids in the colon in physiological and pathologycal conditions (intestinal inflammation) |
| Grantee: | Marco Aurélio Ramirez Vinolo |
| Support Opportunities: | Regular Research Grants |