In vitro and in vivo determination of toxicological profile of nanoformulations

• Grant number: 16/03765-6
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): July 01, 2016
• Effective date (End): September 30, 2019
• Field of knowledge: Interdisciplinary Subjects
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Marcelo Bispo de Jesus
• Grantee: Monique Culturato Padilha Mendonça
• Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/03002-7 - Internalization and intracellular trafficking of nanoparticles: biological activity and nanotoxicological profile, AP.JP
• Associated scholarship(s): 18/24658-9 - Use of N-acetylcysteine in remediation of silver nanoparticles-contaminated soil: toxicokinetics and toxicodynamics approach on Enchytraeus crypticus, BE.EP.PD 17/18867-1 - Toxicological assessment of nanomaterials in soil invertebrate species, BE.EP.PD

Abstract

Nanomaterials are already present in many aspects of our everyday lives: our cars, houses, electronics, drugs and even in our food. However, while nanotechnology revolutionizes the society by introducing new products, it also brings a growing concern about the risks associated with their widespread use. In this context, studies designed to sustainable development and safe applications of nanotechnology are essential, since regulatory frameworks for nanotoxicology trials have not been established. This proposal aims to assess the biosecurity of two distinct and innovative nanomaterials, NanoAgri and NanoCarb subprojects. NanoAgri will assess the toxicity of poly-µ-caprolactone nanocapsules containing atrazine for use in agriculture, with a great economic and social potential. Whereas NanoCarb will assess the toxicity of carbon nanotubes in the development of scaffolds for the regeneration of peripheral nerves, supporting a safe and revolutionary application of these nanomaterials in the medical field. The multidisciplinarity of the subprojects intend to provide the development of the know-how in nanotoxicology field, contributing to validation of common techniques in the future evaluation of different nanomaterials. In addition, the results of both subprojects will contribute to determination of essential regulatory frameworks for harmonization of methods and study protocols for nanomaterials testing, serving as a link of scientific research transposition into technological applications. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PADILHA MENDONCA, MONIQUE CULTURATO; DE JESUS, MARCELO BISPO; VAN GESTEL, CORNELIS A. M. Protective effect of N-acetylcysteine on the toxicity of silver nanoparticles: Bioavailability and toxicokinetics in Enchytraeus crypticus. Science of The Total Environment, v. 715, MAY 1 2020. Web of Science Citations: 0.

PADILHA MENDONCA, MONIQUE CULTURATO; FERREIRA, LUIZ BANDEIRA; RIZOLI, CINTIA; BATISTA, ANGELA GIOVANA; MAROSTICA JUNIOR, MARIO ROBERTO; DA SILVA, EMANUELI DO NASCIMENTO; CADORE, SOLANGE; DURAN, NELSON; DA CRUZ-HOFLING, MARIA ALICE; DE JESUS, MARCELO BISPO. N-Acetylcysteine reverses silver nanoparticle intoxication in rats. Nanotoxicology, v. 13, n. 3, p. 326-338, MAR 16 2019. Web of Science Citations: 1.

BECHER, TIAGO B.; MENDONCA, MONIQUE C. P.; DE FARIAS, MARCELO A.; PORTUGAL, V, RODRIGO; DE JESUS, MARCELO B.; ORNELAS, CATIA. Soft Nanohydrogels Based on Laponite Nanodiscs: A Versatile Drug Delivery Platform for Theranostics and Drug Cocktails. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 26, p. 21891-21900, JUL 4 2018. Web of Science Citations: 8.

MENDONCA, MONIQUE C. P.; RIZOLI, CINTIA; AVILA, DAIANA S.; AMORIM, MONICA J. B.; DE JESUS, MARCELO B. Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing. FRONTIERS IN ENVIRONMENTAL SCIENCE, v. 5, 2017. Web of Science Citations: 1.