Impact of the betamethasone use in pregnancy on the levels of maternal and newborn triglycerides

• Grant number: 16/16912-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2016
• Effective date (End): November 30, 2017
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Adriana Gomes Luz
• Grantee: Ryana Elyzabeth Do Val Roso
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Introduction: Breastfeeding is a single period from the point of view of the clearance of triglycerides by women, characterized by a high calorie deficit. The calorie deficit is due to high TG incorporation capacity in breast milk, which ensures optimal caloric intake for the newborn. The liver increases VLDL production capacity while the white adipose tissue and skeletal muscle reduce their ability to debug triglycerides in VLDL and chylomicron, due to reduced expression of lipoprotein lipase. In a situation of absence of lactation, this lipid metabolic flux is regulated by a series of hormone, glucocorticoids among these. Cortisol (glucocorticoid) induces an increase of triglycerides due to the inhibition of LPL. Thus, it is important to clarify whether interventions (Betamethasone) routinely used in pregnant women carrying this metabolic adaptation impacts. Objectives: To assess whether the use of betamethasone during pregnancy alters the lipid profile in milk on the 2nd day after delivery and possible changes in this profile are related to changes in triglyceride serum levels of breastfeeding and infant. Subjects and Methods: We propose a prospective cohort study in which volunteers will be allocated into two groups: pregnant women receiving and not receiving betamethasone during pregnancy. The variables are: triglycerides, and HDL cholesterol in the mother's blood triglyceride levels in the newborn blood and TG and cholesterol levels in breast milk. Samples for outcome assessment will be collected two days after the birth, on the day if you hold the heel prick test. Assuming error type I and type II 5% and a power of 95% and a difference of 50% increase in TG in milk after using steroids. It would take 30 treated cases and 30 controls, giving a grand total of 60 women in the study. Data analysis: The initial analysis is to compare the mean (± SEM) of amounts related to triglycerides, cholesterol, HDL, VLDL and LDL maternal serum cholesterol and triglycerides in milk and serum triglycerides newborn women's groups They are receiving and not receiving corticosteroids during pregnancy. (AU)