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Grant number: 14/26852-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2017
Effective date (End): August 31, 2019
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Marilza Vieira Cunha Rudge
Grantee:Giovana Vesentini
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Diabetes mellitus during pregnancy is associated with high levels of urinary incontinence (UI) and pelvic floor muscle dysfunction (PFMD). Our academic research group "Diabetes and Pregnancy - Clinical and Experimental" of the Botucatu Medical School, UNESP since 2004, has held a several translational research in this area. However, there are still some doubts about the direct relationship between gestational hyperglycemia, IU and PFMD. Considering the important participation of the abdominal muscles in the urinary continence mechanisms, our hypothesis is that patients with mild gestational hyperglycemia have changes in muscle function, as the important morphological alterations found in experimental models and, therefore, try to explain the high rates of UI and DMAP in women with gestational diabetes mellitus (GDM). The aim of this study is to analyze the effects of hyperglycemia and gestational UI on the Collagen type I and III, protein expression MHC I, MHC IIa, MHC IIx/d, CnA and CnB and ultrastructure of the rectus abdominis muscle at the time of cesarean section. And with these results allow for effective therapeutic intervention with consistent pathophysiological basis. The statistical analysis, and the choice by comparison tests between variables and groups, will be implemented respecting the conditions determined by the results, characteristics and behavior of the variables.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIOVANA VESENTINI; REGINA EL DIB; LEONARDO AUGUSTO RACHELE RIGHESSO; FERNANDA PICULO; GABRIELA MARINI; GUILHERME AUGUSTO RAGO FERRAZ; IRACEMA DE MATTOS PARANHOS CALDERON; ANGÉLICA MÉRCIA PASCON BARBOSA; MARILZA VIEIRA CUNHA RUDGE. Pelvic floor and abdominal muscle cocontraction in women with and without pelvic floor dysfunction: a systematic review and meta-analysis. Clinics, v. 74, . (16/09710-9, 14/26852-6)
VESENTINI, GIOVANA; BARBOSA, ANGELICA M. P.; DAMASCENO, DEBORA C.; MARINI, GABRIELA; PICULO, FERNANDA; MATHEUS, SELMA M. M.; HALLUR, RAGHAVENDRA L. S.; NUNES, STHEFANIE K.; CATINELLI, BRUNA B.; MAGALHAES, CLAUDIA G.; et al. Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women. PLoS One, v. 15, n. 4, . (16/09710-9, 16/01743-5, 14/26852-6)
VESENTINI, GIOVANA; BARBOSA, ANGELICA M. P.; FLORIANO, JULIANA F.; FELISBINO, SERGIO L.; COSTA, SARAH M. B.; PICULO, FERNANDA; MARINI, GABRIELA; NUNES, STHEFANIE K.; REYES, DAVID R. A.; MARCONDES, JOAO P. C.; et al. Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence. Diabetes Research and Clinical Practice, v. 166, p. 12-pg., . (14/26852-6, 16/09710-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VESENTINI, Giovana. Effects of gestational hyperglycemia and gestational urinary incontinence on rectus abdominis muscle: extracellular matrix, protein expression and ultrastructure. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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