Influence of sexual gender on allergic lung inflammation in normolipidic and hyperlipidic mice exposed to ovalbumin

• Grant number: 16/22722-6
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: May 02, 2017
• End date: May 01, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Gabriel Forato Anhê
• Grantee: Rodrigo Rodrigues e Lacerda
• Supervisor: Clive Peter Page
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: King's College London, England
• Associated to the scholarship: 15/18997-7 - Evaluation of the allergic response in the offspring born to and breastfed by obese and lean mice exposed to ovalbumin., BP.DR

Abstract

Obesity is a serious and growing metabolic disorder, it is estimated that over 30% of the world's population is overweight. This condition can lead to the development of many diseases including hypertension, diabetes, apnea and asthma. Regarding asthma, an inflammatory disease of the respiratory system, this presents several causes, such as allergens, drugs and obesity. Affecting about 18% of the population, asthma is considered a serious and disabling disease especially in children. Epidemiological studies indicate that both obesity and asthma have a higher prevalence in females, with no confirmed evidence of possible causes for this observation. There is also no information in the literature about possible differences that may exist between the respiratory efficiency of male and female individuals with the obese phenotype. Considering that obesity is a striking contemporary feature both men and women, it is necessary studies to report if there are significant changes to asthma between genders, to occur a better and more appropriate clinical management and a greater understanding of the pathophysiology of this difference, if any. To this end it is proposed to use an animal model to determine the incidence of asthma in normolipidic and hyperlipidic mice males and females by making use of standard dedicated nasal front of ovalbumin challenge. It is expected the results to characterize the picture as well the elucidation of possible mechanism of action for the observed response.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES E-LACERDA, RODRIGO; ANHE, GABRIEL FORATO; PAGE, CLIVE PETER; RIFFO-VASQUEZ, YANIRA. Sex differences in the influence of obesity on a murine model of allergic lung inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, v. 50, n. 2, DEC 2019. (16/22722-6, 15/18997-7)

E-LACERDA, RODRIGO RODRIGUES; TEIXEIRA, CAIO JORDAO; BORDIN, SILVANA; ANTUNES, EDSON; ANHE, GABRIEL FORATO. Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring. NUTRIENTS, v. 11, n. 12, DEC 2019. (16/22722-6, 17/20742-2, 17/15175-1, 13/07607-8, 15/18997-7)