Evaluation of effects of exposition to air pollution in the development of the central nervous system by stereological methods

• Grant number: 16/22891-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2017
• End date: December 31, 2017
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Mariana Matera Veras
• Grantee: Victor Yuji Yariwake
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Recent studies have been demonstrating that exposure to atmospheric pollution can harm individual's health in diverse physiologic systems and also in development during gestational period. Studies relate pollution with changes in central nervous system (CNS), but a little is known about the effect of pollutants, such as fine particulate matter (PM2,5), during the development of this system in pre and post natal periods. Thus, the objective of this project is to evaluate the effects of PM2,5 of Sao Paulo's pollution in mice CNS development by stereological methods. The animals were exposed to pollution by means of a particulate concentrator during the development periods of CNS (pre and post natal phases) and the consequences of this treatment will be evaluated by stereology, with gauging of cerebral volume, quantification of neurons and measure of cortex thickness. The results of this project can be useful in the identification of possible changes in tissue's morphology because of pollution, which can be related to nervous system's pathological disorders that affects the population diary exposed to pollutants. (AU)