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Effects of the exposure to particulate matter on the development of acute lung injury induced by LPS.

Grant number: 12/23334-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Luiz Fernando Ferraz da Silva
Grantee:Natália de Souza Xavier Costa
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:08/57717-6 - National Institute for Integrated Analysis of Environmental Risk, AP.TEM


Studies have shown that there is an association with air pollution and increased indices of mortality and morbidity in urban population. These effects are more clearly seen in susceptible individuals that have previous cardio-respiratory diseases and elderly people. The particulate matter is a mixture of suspended solid and liquid droplets and is the most frequently associated pollutant to the health adverse effects of air pollution (e.g. systemic and pulmonary inflammation, decreased lung function and aggravation of asthma and bronchitis. The objective of this study is to examine the impact of urban air pollution on the progression of a pre existent lung inflammation and to evaluate if the progression and response of the lung to inflammation is different in those individuals previously exposed to urban polluted air. The experimental model will use LPS delivered by nebulization to induce Lung injury. Lungs, brochoalveolar lavage and blood serum will be obtained and inflammatory profile will be evaluated by different techniques (immunohistochemistry and ELISA). Lungs morphofunctional evaluation will be conducted using stereological methods.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
. Effects of the exposure to atmospheric particulate matter on the development of LPS-induced acute lung injury (ALI). 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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