Studies have shown that there is an association with air pollution and increased indices of mortality and morbidity in urban population. These effects are more clearly seen in susceptible individuals that have previous cardio-respiratory diseases and elderly people. The particulate matter is a mixture of suspended solid and liquid droplets and is the most frequently associated pollutant to the health adverse effects of air pollution (e.g. systemic and pulmonary inflammation, decreased lung function and aggravation of asthma and bronchitis. The objective of this study is to examine the impact of urban air pollution on the progression of a pre existent lung inflammation and to evaluate if the progression and response of the lung to inflammation is different in those individuals previously exposed to urban polluted air. The experimental model will use LPS delivered by nebulization to induce Lung injury. Lungs, brochoalveolar lavage and blood serum will be obtained and inflammatory profile will be evaluated by different techniques (immunohistochemistry and ELISA). Lungs morphofunctional evaluation will be conducted using stereological methods.
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