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National Institute for Integrated Analysis of Environmental Risk

Grant number: 08/57717-6
Support type:Research Projects - Thematic Grants
Duration: March 01, 2009 - February 29, 2016
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: CNPq - INCTs
Principal Investigator:Thais Mauad
Grantee:Thais Mauad
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated grant(s):15/01204-4 - Equipment approved in grant 08/577717-6: Virtangio, AP.EMU
14/05209-8 - 9th International Conference on air quality - science and application, AR.EXT
13/17874-3 - 8th world Congress on developmental origins of health and disease, AR.EXT
13/12660-5 - Environment and health - bridging south, North, East and west conference of ISEE, ISES and ISIAQ, AR.EXT
Associated scholarship(s):12/23334-9 - Effects of the exposure to particulate matter on the development of acute lung injury induced by LPS, BP.MS
11/01253-4 - The action of the fine particulated material (MP2.5) in gene's profile changes in lung carcinogenesis, BP.PD

Abstract

Environmental health is one of the areas where there is more distance between knowledge and action. There is a considerable amount of evidences relating adverse health outcomes and pollution, but effective actions and public policies confront with economical needs, necessity of creating jobs and conflicts among involved actors. The gap between knowledge and effective actions is wider in developing countries, where the necessity of economical growth is high and risk assessment and perception is less developed. The research team involved in the present proposal believes that the one of the weakest links in the chain of events of economical development is the health impact of some economical decisions in terms of energy options and their sustainability. Because Brazil still has large pristine areas in its territory, environmental research is mostly focused on forests or natural ecosystems, and the human consequences of environmental impacts are somewhat placed in the backstage. However, we must face two important scenarios. First, Brazilian Government moved towards the implementation of biofuels as part of its strategy of energy self-sufficiency. This movement was taken before consistent analyses of the health consequences, expressed either in terms of production and emissions. Second, the economical growth of Brazil expanded enormously the areas potentially impacted by pollution, produced by agriculture, industries, forest fires, automotive emissions and electric generation. Considering the size of Brazilian territory and the uneven distribution of technical and academic capacity to conduct risk assessment studies across the country, it is mandatory to expand research, in terms of quantity, quality and distribution. In other words, good science, risk assessment and economical valuation are the tools necessary to avoid errors inherent to uncontrolled economical growth. What are the main difficulties to be surpassed? First, the variety of knowledge necessary to encompass the main aspects of the energy transition of Brazil: the comparative risk represented by the different types of biofuels and the new risks represented by expansion of pollution frontiers to areas devoid of technological sufficiency. This point implies in the development of competent epidemiological, clinical and toxicological studies Second, the wide spectrum of knowledge necessary to evaluate the risk imposed by the new energy sources and frontiers of pollution points towards the necessity of the creation of research networks that put together the necessary groups of expertise. Finally, it is mandatory to establish a program of education, from elementary school to post-graduation, to increase the participation of environmental health in Brazilian research agenda. These three aspects are the targets of the present proposal. Now, specific points will be discussed. Research Studies on environmental health may be considered from different perspectives. One is that physiological changes and diseases caused by the exposure to subtle environmental changes are a unique opportunity to understand human biology. How exposure to ambient particles influences homeostasis? In what extent chronic exposure to air contaminants deviates people from normal aging? Does exposure to ambient levels of air pollution increases the risk of diseases in adulthood? What are the genetic and epigenetic factors that determined vulnerability to air pollution? These are relevant questions and need to be addressed, either in terms of actual energy and transportation options, but also considering the use of new energy alternatives. This project presents a series of research proposals in highly qualified epidemiological, clinical and toxicological research that will provide useful information on how inhaled toxicants interfere with human health. Other possibility is to focus on the comparative effects of the new fuel alternatives in terms of health impact. It is interesting, but engineers use the expression life cycle of fuels but very seldom take into consideration their impact on human life. At least in Brazil, the adoption of new fuels was ruled by economical factors. When ethanol was introduced in the market as automotive fuel, reasons were economic?... (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Healthy older people tolerate heat stress, but not high humidity 
Less science, more pollution  
Pollution increases the risk of atherosclerosis, even with a healthy diet 

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TIMMERMAN, TIRZA; DE BRITO, JOSE MARA; DE ALMEIDA, NATALIA MADUREIRA; DE ALMEIDA, FRANCINE MARIA; ARANTES-COSTA, FERNANDA MAGALHAES; GUIMARAES, ELIANE TIGRE; FARIA COIMBRA LICHTENFELS, ANA JULIA; RODRIGUEZ FERREIRA RIVERO, DOLORES HELENA; DE OLIVEIRA, REGIANI CARVALHO; AMORIM DE LACERDA, JOAO PAULO; MORAES, JAMILLE MOREIRA; PIMENTAL, DANILO AUGUSTO; SARAIVA-ROMANHOLO, BEATRIZ MANGUEIRA; NASCIMENTO SALDIVA, PAULO HILARIO; VIEIRA, RODOLFO DE PAULA; MAUAD, THAIS. Inflammatory and functional responses after (bio)diesel exhaust exposure in allergic sensitized mice. A comparison between diesel and biodiesel. Environmental Pollution, v. 253, p. 667-679, OCT 2019. Web of Science Citations: 0.
RIBEIRO JUNIOR, GABRIEL; XAVIER COSTA, NATALIA DE SOUZA; BELOTTI, LUCIANO; DOS SANTOS ALEMANY, ADAIR APARECIDA; AMATO-LOURENCO, LUIS FERNANDO; DA CUNHA, PAULA GABRIELA; DURO, STEPHANIE DE OLIVEIRA; RIBEIRO, SUSAN PEREIRA; VERAS, MARIANA MATERA; QUIRINO DOS SANTOS LOPES, FERNANDA DEGOBBI TENORIO; MARCOURAKIS, TANIA; NASCIMENTO SALDIVA, PAULO HILARIO; POLISELLI FARSKY, SANDRA HELENA; MAUAD, THAIS. Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 170, p. 314-323, APR 15 2019. Web of Science Citations: 0.
TEIXEIRA, JULIANA ARAUJO; CASTRO, TERESA GONTIJO; GRANT, CAMERON C.; WALL, CLARE R.; DA SILVA CASTRO, ANA LUCIA; VIEIRA FRANCISCO, ROSSANA PULCINELI; VIEIRA, SANDRA ELISABETE; DIAS MEDICI SALDIVA, SILVIA REGINA; MARCHIONI, DIRCE MARIA. Dietary patterns are influenced by socio-demographic conditions of women in childbearing age: a cohort study of pregnant women. BMC PUBLIC HEALTH, v. 18, MAR 1 2018. Web of Science Citations: 3.
KIEMLE TRINDADE, SERGIO HENRIQUE; SERIANI, ROBSON; LORENZI-FILHO, GERALDO; DE MELLO JUNIOR, JOAO FERREIRA; SENNES, LUIZ UBIRAJARA; NASCIMENTO SALDIVA, PAULO HILARIO; MACCHIONE, MARIANGELA. Effects of organic and inorganic compounds of diesel exhaust particles on the mucociliary epithelium: An experimental study on the frog palate preparation. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 148, p. 608-614, FEB 2018. Web of Science Citations: 2.
HETTFLEISCH, KAREN; BERNARDES, LISANDRA STEIN; CARVALHO, MARIANA AZEVEDO; MANFRE PASTRO, LUCIANA DUZOLINA; VIEIRA, SANDRA ELISABETE; SALDIVA, SILVIA R. D. M.; SALDIVA, PAULO; VIEIRA FRANCISCO, ROSSANA PULCINELI. Short-Term Exposure to Urban Air Pollution and Influences on Placental Vascularization Indexes. ENVIRONMENTAL HEALTH PERSPECTIVES, v. 125, n. 4, p. 753-759, APR 2017. Web of Science Citations: 9.
DOMINUTTI, PAMELA A.; NOGUEIRA, THIAGO; BORBON, AGNES; ANDRADE, MARIA DE FATIMA; FORNARO, ADALGIZA. One-year of NMHCs hourly observations in Sao Paulo megacity: meteorological and traffic emissions effects in a large ethanol burning context. Atmospheric Environment, v. 142, p. 371-382, OCT 2016. Web of Science Citations: 12.
CARVALHO, MARIANA A.; BERNARDES, LISANDRA S.; HETTFLEISCH, KAREN; PASTRO, LUCIANA D. M.; VIEIRA, SANDRA E.; SALDIVA, SILVIA R. D. M.; SALDIVA, PAULO H. N.; FRANCISCO, ROSSANA P. V. Associations of maternal personal exposure to air pollution on fetal weight and fetoplacental Doppler: A prospective cohort study. REPRODUCTIVE TOXICOLOGY, v. 62, p. 9-17, JUL 2016. Web of Science Citations: 13.
SALDIVA DE ANDRE, CARMEN DIVA; DE ANDRE, PAULO AFONSO; ROCHA, FRANCISCO MARCELO; NASCIMENTO SALDIVA, PAULO HILARIO; DE OLIVEIRA, REGIANI CARVALHO; SINGER, JULIO M. Reliability of reflectance measures in passive filters. Atmospheric Environment, v. 92, p. 178-181, AUG 2014. Web of Science Citations: 3.
EL KHOURI MIRAGLIA, SIMONE GEORGES; VERAS, MARIANA MATERA; AMATO-LOURENCO, LUIS FERNANDO; RODRIGUES-SILVA, FERNANDO; NASCIMENTO SALDIVA, PAULO HILARIO. Follow-up of the air pollution and the human male-to-female ratio analysis in Sao Paulo, Brazil: a times series study. BMJ OPEN, v. 3, n. 7 2013. Web of Science Citations: 0.
CANGERANA PEREIRA, FERNANDA ALVES; LEMOS, MIRIAM; MAUAD, THAIS; DE ASSUNCAO, JOAO VICENTE; NASCIMENTO SALDIVA, PAULO HILARIO. Urban, traffic-related particles and lung tumors in urethane treated mice. Clinics, v. 66, n. 6, p. 1051-1054, 2011. Web of Science Citations: 6.

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