Acute effects of aerobic and resistance exercise in inflammatory markers IL-10 and IL-1ra in patients with resistant hypertension: a randomized, controlled crossover trial

• Grant number: 16/14265-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2017
• End date: December 31, 2017
• Field of knowledge: Biological Sciences - Pharmacology - Clinical Pharmacology
• Principal Investigator: Ana Paula Cabral de Faria Modolo
• Grantee: Carolina Souza Gasparetti
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The role of regular physical activity, as well as, its potential benefit on blood pressure (BP) have be investigated in resistant hypertension (RH). This study aims to evaluate the acute effects of either aerobic, resistive or both exercises on inflammatory markers IL-10 and IL-1ra in resistant and controlled hypertensive subjects. Secondly, we will assess those effects on beat-to-beat BP levels. This randomized, single-blind, crossover non-pharmacological intervention study will include 20 patients, 10 RH and 10 controlled hypertensives, who are regularly followed at the Outpatient Resistant Hypertension Clinic/UNICAMP. This study will comprise two parts: (1) to determine the type and duration of each exercise individually for each volunteers, and (2) to perform all the three types of exercise in a crossover way in all subjects. We will perform blood test before and after the interventions to assess inflammatory biomarkers IL-10 and IL-1ra (analyzed by ELISA). Also, we will determine the beat-to-beat BP levels (using the Finometer device). We expect that the acute practice of exercise modulates the inflammatory biomarkers, IL-10 and IL-1ra, and secondly the BP levels, as well as provides a better understanding of this non-pharmacologic treatment in RH, in order to make this more effective in this high-risk population. (AU)