Incidence of HCMV infection in the 1st year after heart transplant according to imunosupression and rejection episodes

• Grant number: 16/14325-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2016
• End date: November 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fernando Bacal
• Grantee: Michel da Silva
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Infection by cytomegalovirus (HCMV) is the most prevalent correlated with the first year after heart transplantation in adults. Despite the promising advances in reducing post - surgery complications, this infection is responsible for increasing the risk of chronic rejection, vascular graft disease and the mortality rate. However, in our institution is scarce literature on the relationship between the incidence of HCMV infection and its relationship with immunosuppressive regimen hindering the progress of cardiac transplantation. Objectives: Analyze the incidence of HCMV infection in the first year after heart transplant and its correlation with immunosuppressive therapy and previous rejection episodes. Methods: All patients submitted to heart transplant between jan/2013 and jul/2014 will be included in the study. A retrospective analysis of electronic medical records will be done to obtain information about renal function, electrolytes, vasoactive drugs and immunosuppressive therapy. A prospective analysis of electronic medical records will also be done to identify HCMV infection all over the first year after heart transplant. The presence of HCMV infection will be analyzed according to immunosuppressive therapy and to previous cellular or antibody mediated rejection. (AU)