Identification of putative ligands activating G-protein coupled receptors, GprH, GprM and GprI, in Aspergillus nidulans

• Grant number: 17/02464-5
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: June 20, 2017
• End date: December 19, 2017
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Gustavo Henrique Goldman
• Grantee: Laura Mellado Maronas
• Supervisor: Neil Andrew Brown
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Rothamsted Research, England
• Associated to the scholarship: 15/12415-6 - Functional characterization of GprH, GprI and GprM G-protein coupled receptors (GPCRs) in the model organism Aspergillus nidulans., BP.PD

Abstract

Fungal G-protein signalling coordinates development, mycotoxin production, quorum sensing and pathogenesis in multiple species. G-protein coupled receptors (GPCRs) communicate changes in the extracellular environment to intracellular signalling events through G-proteins, that initiate and direct the appropriate transcriptional response. However, the role of GPCRs and their activating ligands is largely unknown. This project will provide a complimentary multidisciplinary approach to investigate, using heterologous expression systems and electrophysiology, the function of GPCRs from the model filamentous mycotoxigenic fungus, and opportunistic human pathogen, Aspergillus nidulans.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS REIS, THAILA FERNANDA; MELLADO, LAURA; LOHMAR, JESSICA M.; SILVA, LILIAN PEREIRA; ZHOU, JING-JIANG; CALVO, ANA M.; GOLDMAN, GUSTAVO H.; BROWN, NEIL A.. GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production. PLOS GENETICS, v. 15, n. 10, OCT 2019. (17/02464-5, 18/22040-8, 15/12415-6)