Biochemical studies of a serine protease from snake venom

• Grant number: 16/21682-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2017
• End date: March 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ljubica Tasic
• Grantee: Giovanna Rivabem Grillo
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Among the substances produced by the exocrine glands of snake as venom, two important and most prominent enzymes are the metallo- and serine proteases, which are responsible for changes in the haemostatic system of the victims of snakebites. This project emphasizes the study of a serine protease, named SVSP1 (Snake Venom Serine Protease 1), which catalytic system is composed from the catalytic triad, with high substrate specificity and is capable of converting fibrinogen to fibrin, causing systemic disorders. Our studies focus on the biochemical activity of the SVSP1, which source is the venom of Bothrops asper (courtesy of Instituto Clodomiro Picado, Costa Rica in the lyophilised form) in the presence of hesperetin. We hope to prove low detectability or no detectability in vitro of this SVSP1 serine protease when hesperetin is present. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS SANTOS, RONEY VANDER; GRILLO, GIOVANNA; FONSECA, HENRIQUE; STANISIC, DANIJELA; TASIC, LJUBICA. Hesperetin as an inhibitor of the snake venom serine protease from Bothrops jararaca. Toxicon, v. 198, p. 64-72, JUL 30 2021. (16/21682-0)