Characterization of histopathological changes and cellular immune response in cutaneous lesions of patients with Tegumentary Leishmaniasis in Panamá

• Grant number: 17/03141-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: April 01, 2017
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Marcia Dalastra Laurenti
• Grantee: Kadir Amilcar Gonzalez Carrion
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 14/50315-0 - Leishmaniasis in Latin America: an advanced perspective on immunopathogenetic factors of cutaneous and visceral infection, immunomodulators of the sandflies vector saliva and immunogenic exo-antigens of Leishmania (L.) infantum chagasi as vaccine candidates, AP.TEM

Abstract

Leishmaniasis is the zoonosis with the highest incidence in the rural population of Panama. Approximately 3000 new cases have been registered annually in the country, and the same number of cases without a confirmatory diagnosis is estimated. This register is due to the chronicity of the infection and to the fact that the disease occurs mainly in poor rural populations, usually far from the health laboratories with the capacity to diagnose the infection. In view of this, this study aims to improve the parasitological diagnosis of the disease, as well as to characterize histopathologically the cutaneous lesions and cellular immune response in situ in Panamanian patients affected by cutaneous leishmaniasis using the immunohistochemistry technique. It is hoped that the results obtained will help to better define the magnitude and pathogenesis of this parasitic disease in Panama and thus better guide the control strategies and/or improve their management. In addition, the characterization of the histopathological changes and aspects of cellular immunity in cutaneous lesions caused by L. (V.) panamensis will provide a greater subsidy in the studies related to the spectrum of American Tegumentary Leishmaniasis (ATL) that has been the object of study of our search group. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONZALEZ, KADIR; CALZADA, JOSE EDUARDO; TOMOKANE, THAISE YUMIE; SANDOVAL PACHECO, CARMEN MARIA; ARAUJO FLORES, GABRIELA VENICIA; CASTRO GOMES, CLAUDIA MARIA; PEREIRA CORBETT, CARLOS EDUARDO; SALDANA, AZAEL; LAURENTI, MARCIA DALASTRA. In situ study of cellular immune response in human cutaneous lesions caused by Leishmania (Viannia) panamensis in Panama. PARASITE IMMUNOLOGY, v. 43, n. 3, OCT 2020. (17/03141-5, 14/50315-0)

GONZALEZ, K.; CALZADA, J. E.; CORBETT, C. E. P.; SALDANA, A.; LAURENTI, M. D.. Involvement of the Inflammasome and Th17 Cells in Skin Lesions of Human Cutaneous Leishmaniasis Caused by Leishmania (Viannia) panamensis. Mediators of Inflammation, v. 2020, OCT 28 2020. (17/03141-5, 14/50315-0)

GONZALEZ, K.; CALZADA, J. E.; DIAZ, R.; PAZ, H.; GARCIA, V.; MIRANDA, A.; TOMOKANE, T.; PUGA, S.; SALDANA, A.; LAURENTI, M.. Performance of immunohistochemistry as a useful tool for the diagnosis of cutaneous leishmaniasis in Panama, Central America. Parasitology International, v. 71, p. 46-52, AUG 2019. (14/50315-0, 17/03141-5)

KADIR GONZÁLEZ; ROSENDO DIAZ; AUREA F. FERREIRA; VÍCTOR GARCÍA; HÉCTOR PAZ; JOSÉ E. CALZADA; MICHELLE RUÍZ; MÁRCIA LAURENTI; AZAEL SALDAÑA. Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama. Revista do Instituto de Medicina Tropical de São Paulo, v. 60, 2018-02-15. (17/03141-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARRION, Kadir Amilcar Gonzalez. Characterization of histopathological changes and cellular immune response in cutaneous lesions of patients with cutaneous leishmaniosis in Panama. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.