Effects of SAA on keratinocytes

• Grant number: 16/24758-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2017
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Elaine Hatanaka Dermargos
• Grantee: Beatriz Belmiro Dias
• Host Institution: Centro de Ciências Biológicas e da Saúde. Universidade Cruzeiro do Sul (UNICSUL). São Paulo , SP, Brazil

Abstract

During the acute phase response, SAA can displace apoA-I from HDL. Because of the association of apoA-I with HDL particles, SAA was thought to be involved in lipid metabolism, altering fatty acid levels in the site of inflammation, and thus influencing the skin healing. The keratinocytes form the outer layers of the epidermis and in addition to being important for the maintenance of skin integrity, participate in the immune response and wound healing by release of cytokines (TNF-±, IL-1², IL-6), chemokines (IL -8, IPM) and growth factors (VEGF and FGF). This study aims to investigate the effect of SAA in keratinocytes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELMIRO, B.; WEIMANN, E.; DERMARGOS, A.; HATANAKA, E.. Serum amyloid a induces cytokine and growth factor production in HaCaT keratinocytes. FEBS OPEN BIO, v. 8, p. 1-pg., 2018-07-01. (16/24758-8)