Role of protein and sirtuins acetylation in T. cruzi infection process

• Grant number: 17/02496-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2017
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Biochemistry of Microorganisms
• Principal Investigator: Sergio Schenkman
• Grantee: Amaranta Muniz Malvezzi
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 15/22031-0 - Cell signaling in Trypanosoma during host-parasite interaction, AP.TEM

Abstract

As described in the main project, the aim of this subproject is to investigate whether protein acetylation is involved in the control of reactive oxygen species in T. cruzi. Among 267 acetylated proteins, we found a large preference for proteins related to the oxidative stress response. More specifically, we intend to: 1) test whether acetylation regulates the activity of enzymes involved in the oxidative stress responses in T. cruzi; 2) test whether sirtuins have a role in this process; 3) understand how sirtuin expression and activity is regulated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTRO MACHADO, FABRICIO; BITTENCOURT-CUNHA, PAULA; MALVEZZI, AMARANTA MUNIZ; ARICO, MIRELLA; RADIO, SANTIAGO; SMIRCICH, PABLO; ZOLTNER, MARTIN; FIELD, MARK C.; SCHENKMAN, SERGIO. EIF2 alpha phosphorylation is regulated in intracellular amastigotes for the generation of infectiveTrypanosoma cruzitrypomastigote forms. Cellular Microbiology, v. 22, n. 11, JUL 2020. (14/01577-2, 17/02496-4)