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Investigating the neural substrates of temporal task learning

Grant number: 17/03729-2
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): July 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Marcelo Bussotti Reyes
Grantee:Eliezyer Fermino de Oliveira
Supervisor abroad: Gyorgy Buzsaki
Home Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Research place: NYU Langone Medical Center, United States  
Associated to the scholarship:16/05473-2 - Eletrophysiologycal caracterization of prefrontal-striatal pathway activity in temporal task learning, BP.MS


Perceiving time is important to prepare a behavioral outcome, for example, a walking person needs to know whether he can cross a road or not by estimating if he will have enough time for it before a car comes. Understanding how we learn to time a particular interval is intrinsic to increase our comprehension of time perception and interval time acquisition. Different theories and studies look to unveil the neural basis of this temporal learning. Hippocampus (HPC) and medial prefrontal cortex (mPFC) play a role in a variety of timing tasks. Besides, our preliminary results suggest that temporal tasks are learned in an abrupt way, not gradually, as is the gradual traditional view. Our aim is to study the HPC and mPFC interaction in a timing task learning. To accomplish such objectives, we are going to massively record both areas with silicon probes (256 channels each) while animal learns a temporal bisection task. Also, we are going to disconnect both areas with optogenetics and a closed-loop approach in off-task periods, where propitious states of learning occur. This will allow us to study (i) HPC-mPFC network interactions in both LFP and spike level. (ii) Identify how does HPC-mPFC change after learning a time task. (iii) Study the causality between HPC-mPFC interaction and timing learning.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVA, AZAHARA; FERNANDEZ-RUIZ, ANTONIO; DE OLIVEIRA, ELIEZYER FERMINO; BUZSAKI, GYORGY. Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples. CELL REPORTS, v. 25, n. 7, p. 1693+, . (17/03729-2)
FERNANDEZ-RUIZ, ANTONIO; OLIVA, AZAHARA; DE OLIVEIRA, ELIEZYER FERMINO; ROCHA-ALMEIDA, FLORBELA; TINGLEY, DAVID; BUZSAKI, GYORGY. Long-duration hippocampal sharp wave ripples improve memory. Science, v. 364, n. 6445, SI, p. 1082+, . (17/03729-2)

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