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Predictive potential of urinary biomarkers for early diagnosis of acute kidney injury in relevant clinically situations

Grant number: 17/06332-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Leila Antonangelo
Grantee:Lia Junqueira Marçal
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:14/19286-4 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects, AP.TEM


Acute Kidney Injury (AKI) incidence has increased significantly in the last years, and AKI has emerged as a worldwide health public problem. In fact, AKI has been associated with higher morbidity and early and late mortality, higher hospital length of stay and development of Chronic Kidney Diseases (CKD). In this context, AKI early diagnosis is extremely important to increase protective measures to prevent and minimize the AKI development. Currently, the laboratory diagnosis is based on the increase of the serum creatinine levels. However, serum creatinine changes may occur hours or days after the decrease of the glomerular filtration ratio, and the creatinine concentration is influenced by many non renal factors such as age, muscular mass and metabolism, drugs, hydration and nutritional status, creatinine tubular secretion and gender. Additionally, serum creatinine levels increase only after the decrease of at least 50% of renal filtration reserve. In this context, nowadays there is an intense research trying to identify adequate biomarkers, which can predict an early diagnosis of IRA. This study aim to analyze the efficiency of 12 urinary biomarkers in detecting early changes in renal injury, regarding the development of AKI diagnosed by serum creatinine level criteria in high risk and clinically relevant situations to AKI development: non vascular electives surgeries, moderate to severe trauma and clinical emergencies patients. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARÇAL, Lia Junqueira. Predictive potential of urinary biomarkers for early diagnosis of acute kidney injury in major elective abdominal non-vascular surgeries. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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