Modulator effect of ionizing radiation on blood cytokines in rats submitted to implants surgery

• Grant number: 17/04389-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2017
• End date: May 31, 2018
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Luana Marotta Reis de Vasconcellos
• Grantee: Sarah de Oliveira Marco Avelino
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Dental implants are considered as effective rehabilitation treatment. However, the success of osseointegration is associated with peri-implant tissue health. Several factors can impair the receptor site, among them, radiotherapy, which is the procedure unqualified release of irradiation in specific areas, aimed at treatment of tumors. However, the mechanisms by which radiotherapy interfere with osseointegration have not yet been fully elucidated. The objective of this study is to evaluate the modulating effect of radiotherapy on the expression of blood cytokines in rats submitted to implant surgery. It will be used in this study 72 mice that receive threaded titanium implants commercially pure grade 2 (cpTi) the right femurs. The animals will be divid into 4 groups: a) implant Group (Ip): implant placement surgery; b) early irradiation group (IrP): implant placement of irradiation implants after 1 day; c) late irradiation group (IRT): implantation surgery and irradiation after 4 weeks; d) irradiation group (Ir): irradiation and after 4 weeks implant placement surgery. The animals of the IrI, IrT and Ir groups will be submitted to a 30 Gy irradiation. Plasma levels of IL-6, TGF-², will be measured prior to euthanasia, which will be 3 days, 2 weeks and 6 weeks after treatment (n = 06). All data are statistically analyzed, initially by means of the normality test (p <0.05).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA FONSECA, GABRIELA FERNANDES; MARCO AVELINO, SARAH DE OLIVEIRA; REIS MELLO, DAPHNE DE CAMARGO; DO PRADO, RENATA FALCHETE; BASTOS CAMPOS, TIAGO MOREIRA; REIS DE VASCONCELLOS, LUANA MAROTTA; TRICHES, ELIANDRA DE SOUSA; SOUTO BORGES, ALEXANDRE LUIZ. Scaffolds of PCL combined to bioglass: synthesis, characterization and biological performance. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 31, n. 5, APR 29 2020. (17/04389-0)

VEGIAN, MARIANA RAQUEL DA CRUZ; COSTA, BRUNO CESAR ALMEIDA; SANTANA-MELO, GABRIELA DE FATIMA; GODOI, FERNANDA HERRERA COSTA; KAMINAGAKURA, ESTELA; TANGO, RUBENS NISIE; DO PRADO, RENATA FALCHETE; DE OLIVEIRA, LUCIANE DIAS; FEDERICO, CLAUDIO ANTONIO; AVELINO, SARAH DE OLIVEIRA MARCO; et al. Systemic and local effects of radiotherapy: an experimental study on implants placed in rats. CLINICAL ORAL INVESTIGATIONS, v. 24, n. 2, p. 785-797, FEB 2020. (17/04389-0, 17/00543-5, 16/19707-5, 15/24986-8)